2024年5月6日 · SSTR4. Studies have determined that somatostatin receptor subtype 4 (SSTR4) plays an important role in controlling several brain functions based on the following observations: • Experimental studies using bacTRAP technology have indicated that SSTR4 is highly expressed in areas of the brain involved in learning and memory processes

Stimulation of somatostatin receptor 4 (SSTR4) inhibits nociception in animals, and SSTR4 knockout mice have heightened responses to painful stimuli compared with wild-

2013年5月17日 · Somatostatin plays a critical role in the regulation of processes such as cellular proliferation, glucose homeostasis, inflammation, and pain. It is believed to inhibit nociceptive and inflammatory processes via the SSTR4 pathway.

2024年12月25日 · SSTR4 (Somatostatin Receptor 4) is a Protein Coding gene. Diseases associated with SSTR4 include Prolactinoma and Sotos Syndrome. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

2019年12月11日 · Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via the somatostatin sst 4 receptor without endocrine actions. Therefore, sst 4 is considered to be a novel target for drug development in pain including chronic neuropathy, which is an emerging unmet medical need.

2024年5月2日 · Somatostatin 4 receptor (SSTR4) has been shown to mediate anxiolytic and depression-like effects. Here, we aimed to explore the potential of SSTR4 as a diagnostic marker for chronic stress in...

Somatostatin exerts its effects via binding to G-protein-coupled somatostatin receptors of which the fourth subtype (SSTR4) is a particularly important receptor mediating analgesic, anti-inflammatory, and anti-depressant effects without endocrine actions.

SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008] somatostatin receptor type 4, G-protein coupled receptor.

Somatostatin receptors (SSTR) are expressed in various neoplasms and can be targeted for both diagnostics as well as therapeutics. This systematic review aims to compile and discuss the prevalence of somatostatin receptor expression in various neoplasms.

2020年11月1日 · Somatostatin mediates potent analgesic and anti-inflammatory actions. Sst 4 agonists are promising drug candidates for neuropathic pain. We created the 3-dimensional structure of sst 4 receptor. We characterized the binding of our novel small molecule sst 4 …