Dec 25, 2024 · This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in …

Nov 5, 2023 · Our study demonstrates that SREBF1 controls the balance of lipid synthesis, uptake, storage and liberation to maintain lipid homeostasis for rapid tumor growth, while suggesting it as a very promising molecular target for cancer treatment.

SREBF1 is 24,940 bases long and is located at 17p11.2. It encodes the sterol regulatory element binding transcription factor 1, which is a transcriptional activator with a role in lipid homeostasis.

Feb 23, 2025 · We constructed a risk score based on SREBF1 target genes associated with the biochemical recurrence of prostate cancer by combining bulk RNA analysis. Finally, we verified the effects of the...

SREBF1 is a novel loci for schizophrenia susceptibility and controlled cholesterol biosynthesis. SREBP-1c 54G/C single nucleotide polymorphism is associated with nonalcoholic fatty liver disease.

Gene ID: 20787, updated on 8-Feb-2025. This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis.

Sterol regulatory element-binding protein-1 (SREBP1) and SREBP2 (600481) are structurally related proteins that control cholesterol homeostasis by stimulating transcription of sterol-regulated genes (summary by Osborne, 2001).

Feb 8, 2025 · Knockdown of Srebf1 resulted in a significant down-regulation of Selenop expression. The involvement of SREBP-1c in FASN promoter histone modification. Data show that TO901317 increased expression of both Liver X receptors (LXRalpha and LXRbeta) isoforms and its target genes: sterol response element binding protein 1c (SREBP-1c) and acetyl ...

Dec 1, 2011 · Our data suggest that srebf1a acts as an essential link between the GSK3β-C/EBPβ signaling axis and the beginning of the adipogenic transcriptional cascade. White adipose tissue plays an important...

Feb 14, 2025 · This study provided genetic evidence indicating that indivduals with MS face higher risk of coronary heart disease. Furthermore, SREBF1 maybe a critical target gene which would significantly contribute to drug development.