2024年12月25日 · This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is …

2023年11月5日 · Our study demonstrates that SREBF1 controls the balance of lipid synthesis, uptake, storage and liberation to maintain lipid homeostasis for rapid tumor growth, while …

SREBF1 is 24,940 bases long and is located at 17p11.2. It encodes the sterol regulatory element binding transcription factor 1, which is a transcriptional activator with a role in lipid homeostasis.

SREBF1 is a novel loci for schizophrenia susceptibility and controlled cholesterol biosynthesis. SREBP-1c 54G/C single nucleotide polymorphism is associated with nonalcoholic fatty liver …

2025年2月23日 · SREBF1 significantly influences metabolic reprogramming in prostate cancer cells, leading to ferroptosis resistance. Importantly, our results demonstrated that SREBF1 …

2025年2月23日 · We constructed a risk score based on SREBF1 target genes associated with the biochemical recurrence of prostate cancer by combining bulk RNA analysis. Finally, we …

Gene ID: 20787, updated on 8-Feb-2025. This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein …

2025年2月8日 · Knockdown of Srebf1 resulted in a significant down-regulation of Selenop expression. The involvement of SREBP-1c in FASN promoter histone modification. Data show …

Sterol regulatory element-binding protein-1 (SREBP1) and SREBP2 (600481) are structurally related proteins that control cholesterol homeostasis by stimulating transcription of sterol …

2025年2月14日 · This study provided genetic evidence indicating that indivduals with MS face higher risk of coronary heart disease. Furthermore, SREBF1 maybe a critical target gene …