SOX17 - Wikipedia
SOX17 is involved in the regulation of vertebrate embryonic development and in the determination of the endodermal cell fate. The encoded protein acts downstream of TGF beta signaling (Activin) and canonical WNT signaling (Wnt3a).
SOX17 Gene - GeneCards | SOX17 Protein | SOX17 Antibody
Dec 25, 2024 · SOX17 (SRY-Box Transcription Factor 17) is a Protein Coding gene. Diseases associated with SOX17 include Vesicoureteral Reflux 3 and Familial Vesicoureteral Reflux. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Signaling by WNT.
SOX17 enables immune evasion of early colorectal adenomas and …
Feb 28, 2024 · We propose that SOX17 is a transcription factor that is engaged during the early steps of colon cancer to orchestrate an immune-evasive programme that permits CRC initiation and progression.
SOX17 SRY-box transcription factor 17 [ (human)] - National …
Feb 8, 2025 · SOX17 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC. Decreased Sox17 expression is correlated with melanoma progression, an unfavorable survival of melanoma patients and …
Sox17 is required for endothelial regeneration following ... - Nature
May 9, 2019 · We identify Sox17 as a key regulator of endothelial cell regeneration using endothelial-specific deletion and overexpression of Sox17. Endotoxemia upregulates Hypoxia inducible factor 1α, which...
How early-stage cancer cells hide from the immune system
Feb 28, 2024 · Precancerous colon cells can avoid immune detection by turning on a gene called SOX17, which allows them to become essentially invisible to the immune system, an MIT study finds.
Sox17 is indispensable for acquisition and maintenance of arterial ...
Oct 24, 2013 · Here we report that the transcription factor Sox17, which is known as a regulator of endoderm and hemopoietic differentiation, is selectively expressed in arteries, and not in veins, in the...
SOX17 is a critical specifier of human primordial germ cell fate
Jan 15, 2015 · Remarkably, SOX17 is the key regulator of hPGC-like fate, whereas BLIMP1 represses endodermal and other somatic genes during specification of hPGCLCs.
SOX17 SRY-box transcription factor 17 [ Homo sapiens (human) ]
Dec 10, 2024 · Title: SOX17 is a Critical Factor in Maintaining Endothelial Function in Pulmonary Hypertension by an Exosome-Mediated Autocrine Manner. Dysregulation of SOX17/NRF2 axis confers chemoradiotherapy resistance and emerges as a novel therapeutic target in esophageal squamous cell carcinoma.
SOX17: A Highly Sensitive and Specific Immunomarker for
Through mining The Cancer Genome Atlas mRNA expression profile data, we identified SOX17 as a potential specific marker at the mRNA level for gynecologic tumors.