Apr 27, 2021 · SMARCA4 (BRG1), SMARCA2 (BRM) or SMARCB1 (INI1) aberrant loss (Dis Esophagus 2009;22:1, Am J Surg Pathol 2021;45:414) Sample pathology report Esophagus, biopsy:

Jun 1, 2022 · SMARCB1 (switch / sucrose non fermentable [SWI / SNF] related, matrix associated, actin dependent regulator of chromatin subfamily B member 1) is located on chromosome 22q11.2 and encodes a core subunit of the adenosine triphosphate (ATP) dependent SWI / SNF chromatin remodeling complex, which is actively involved in the …

O-Z: perivascular epithelioid cell tumor (PEComa) POLE ultramutated endometrial carcinoma progestin therapy related changes serous carcinoma SMARCA4 deficient uterine sarcoma smooth muscle tumors of uncertain malignant potential staging-carcinoma and carcinosarcoma staging-sarcoma undifferentiated / dedifferentiated carcinoma (endometrium ...

Jun 21, 2023 · 4 genetically defined groups and 4 histologically defined groups (Nature 2017;547:311) Genetically defined: (a) WNT (for wingless integration site) activated, (b) SHH (sonic hedgehog) activated (either TP53 mutant or TP53 wild type), non-WNT / non-SHH, either (c) medulloblastoma group 3 or (d) medulloblastoma group 4 (Nature 2017;547:311)

Soft tissue: AE1 / AE3 ALK1 caldesmon CAMTA1 CCNB3 (pending) CD31 CD34 CD99 CDK4 D2-40 DDIT3 (pending) desmin DOG1 DUX4 EBER EMA ERG factor XIIIa FLI1 FOSB (pending) GLUT1 H3K27me3 HHV8 / LANA1 HMB45 c-kit / CD117 MDM2 MelanA MUC4 MYOD1 myogenin NKX2.2 (pending) NR4A3 (pending) pan-TRK PROX1 (pending) RB1 S100 SDHB …

Jul 11, 2024 · SMARCA4 deficient carcinomas are histologically undifferentiated, composed of large epithelioid anaplastic cells in nests and trabeculae; diffuse loss of BRG1 staining by IHC is definitional NUT carcinoma: Sheets and nests of small to intermediate sized undifferentiated cells with a monomorphic appearance

Aug 29, 2024 · Comment: The biopsy shows mixture of epithelial, mesenchymal and neuroepithelial components. The presence of fetal-like clear cell appearance in the epithelial islands and loss of SMARCA4 (BRG1) stain in the tumor are consistent with the above diagnosis. The tumor has propensity for lung metastases.

Aug 8, 2023 · Squamous cell carcinoma is a malignant tumor arising from epithelial cells with squamous differentiation demonstrated either immunohistochemically or morphologically, with the presence of keratinization or intercellular bridges

Aug 26, 2021 · Sertoli-Leydig cell tumor is a rare ovarian tumor composed of sex cord (Sertoli cells) and stromal (Leydig cells) elements, accounting for < 0.5% of all ovarian neoplasms

BAP1 is functionally a tumor suppressor (Proc Natl Acad Sci USA 2014;111:285) BAP1 is a deubiquitinase that associates with multiprotein complexes that regulate key cellular pathways, including the cell cycle, cellular differentiation, cell death, gluconeogenesis and the DNA damage response (Nat Rev Cancer 2013;13:153)