Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene. [5] [6]

Dec 25, 2024 · Complete information for SMARCA2 gene (Protein Coding), SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 2, including: function, proteins, …

Herein, we present development of a potent and selective SMARCA2 degrader, structurally unrelated to known chemotypes with first in class potential selectively targeting SMARCA4 …

Nov 10, 2022 · Selective SMARCA2 degradation is achieved in the absence of selective SMARCA2/4 PROTAC binding and translates to potent in vitro growth inhibition and in vivo …

SMARCA2 has been identified as a key synthetic lethal target in SMARCA4-deficient cancers, yet the mechanism underlying the synthetic lethal relationship is unclear.

The SMARCA2 gene provides instructions for making one piece (subunit) of a group of similar protein complexes known as SWI/SNF complexes. These complexes regulate gene activity …

5 days ago · SMARCA2 is an ATPase that regulates chromatin structure via ATP pathways, controlling cell division and differentiation. SMARCA2's bromodomain and ATPase domain, …

BAF requires either SMARCA2 (BRM) or SMARCA4 (BRG1), mutually exclusive ATPase subunits, for chromatin remodeling to occur. Inhibiting SMARCA2 in SMARCA4-deficient …

Using the TPD approach, Prelude is developing highly potent and selective SMARCA2 protein degraders designed to specifically inhibit SMARCA4-deficient tumors.

• Selective SMARCA2 degradation modulates gene expression via transcriptional regulation in sensitive cell lines, enabling the identification of robust biomarkers