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Probable global transcription activator SNF2L2 is a protein that in humans is encoded by the SMARCA2 gene. The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are … 展开
• Aves SJ, Hindley J, Phear GA, Tongue N (Aug 1995). "A fission yeast gene mapping close to suc1 encodes a protein containing two bromodomains". … 展开
CC-BY-SA 许可证中的维基百科文本 SMARCA2 Gene - GeneCards | SMCA2 Protein | SMCA2 …
2024年12月25日 · SMARCA2 is a protein coding gene that encodes a subunit of the SWI/SNF chromatin remodeling complex, involved in transcriptional activation and repression. It is associated with several diseases, such as Nicolaides …
《普创新》探索表观遗传学合成致死新搭 …
SMARCA2/4是SWI/SNF复合物中重要的催化亚基，参与染色质重塑和基因转录调节，在多种癌症中发生突变。本文概述了SMARCA2/4的结构、功能、突变类型和药物研发进展，特别介绍了Foghorn公司的SMARCA2/4双抑制剂FHD-286的 …
SMARCA2 protein: Structure, function and perspectives of drug …
SMARCA2 is an ATPase that regulates chromatin structure via ATP pathways, controlling cell division and differentiation. SMARCA2's bromodomain and ATPase domain, crucial for …
合成致死靶点SMARCA2抑制剂的研究进展及专利分析医药新闻-ByD…
2024年10月28日 · 靶向smarca2分子开发有两条主要的途径: 一是基于溴结构域的蛋白降解剂(见前期文章: 合成致死靶点smarca2: protac蛋白降解剂 (专利综述) )。 另一条是靶向 SMARCA2 …
近9亿美元！一项针对靶向SMARCA2 PROTAC的交易刚刚达成
2024年8月2日 · smarca2对于smarca4中具有功能丧失突变的肿瘤细胞生长至关重要，是smarca4突变癌症中关键且有希望的治疗靶点。此外，smarca4缺陷的患者群体通常缺乏可靶 …
合成致死靶点——SMARCA2/4靶向药物研究进展 - Pharmcube
2024年6月25日 · 本文介绍了SMARCA2和SMARCA4是一类染色质重塑复合物上的核心ATPase，参与表观遗传调控，与多种癌症相关。文章还转载了一些关于SMARCA2/4靶向药 …
Selective PROTAC-mediated degradation of SMARCA2 is ... - Nature
2022年11月10日 · Selective SMARCA2 degradation is achieved in the absence of selective SMARCA2/4 PROTAC binding and translates to potent in vitro growth inhibition and in vivo …
SMARCA2 SWI/SNF related BAF chromatin remodeling complex …
SMARCA2 Is a Novel Interactor of NSD2 and Regulates Prometastatic PTP4A3 through Chromatin Remodeling in t(4;14) Multiple Myeloma. Two cases of Nicolaides-Baraitser …
SMARCA2 SWI/SNF related BAF chromatin remodeling complex …
2025年1月4日 · Positional proteomics analysis identifies the cleavage of human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 …
