I-Smad （包括 Smad6 和 Smad7 ）是 TGF-β 信号的关键负调控因子；它们本身是 TGF-β /BMP 的靶基因，因此形成负反馈的调控模式 [5] 。 Smad7 是 TGF- β 家族的广谱抑制蛋白，而 Smad6 更特异性的抑制 BMP 信号，尤其是 ALK3/6 介导的信号。

2022年11月21日 · SMAD6 encodes an intracellular inhibitor of the bone morphogenetic protein (BMP) signalling pathway. Until now, SMAD6-deficiency has been associated with three distinctive human congenital...

2024年12月25日 · SMAD6 (SMAD Family Member 6) is a Protein Coding gene. Diseases associated with SMAD6 include Aortic Valve Disease 2 and Craniosynostosis 7. Among its related pathways are Gene expression (Transcription) and TGF …

SMAD6 encodes an intracellular inhibitor of the bone morphogenetic protein (BMP) signalling pathway. Until now, SMAD6-deficiency has been associated with three distinctive human congenital conditions, i.e., congenital heart diseases, including left ventricular obstruction and conotruncal defects, craniosynostosis and radioulnar synostosis.

2018年6月27日 · In this study, we report that Smad6 is overexpressed in nuclei of glioma cells, which correlates with poor patient survival and regulates STAT3 activity via negatively regulating the Protein...

2024年6月25日 · smad6是bmp信号通路的主要抑制因子。 SMAD6一方面可以招募E3泛素连接酶，降解BMP I型受体蛋白，从而抑制I型受体磷酸化激活BMP信号传递核心SMAD1/5/8；另一方面，SMAD6竞争结合SMAD1/5/8，阻止SMAD1-SMAD4激活复合物的形成，从而阻遏BMP信号转导。

SMAD6 overexpression leads to accelerated myogenic differentiation of LMNA mutated cells. A novel SMAD6 variant was identified in a patient with severely calcified bicuspid aortic valve and thoracic aortic aneurysm. Data indicate two individuals with biallelic missense variants in SMAD6 and a complex cardiac phenotype.

2022年11月21日 · SMAD6 encodes an intracellular inhibitor of the bone morphogenetic protein (BMP) signalling pathway. Until now, SMAD6-deficiency has been associated with three distinctive human congenital conditions, i.e., congenital heart diseases, including left ventricular obstruction and conotruncal defects, cr …

Smad6 inhibits BMP/Smad1 signaling without interfering with receptor-mediated phosphorylation of Smad1. Smad6 specifically competes with Smad4 for binding to receptor-activated Smad1, yielding an apparently inactive Smad1–Smad6 complex. Therefore, Smad6 selectively antagonizes BMP-activated Smad1 by acting as a Smad4 decoy.

2025年2月8日 · Title: SMAD6 transduces endothelial cell flow responses required for blood vessel homeostasis. Genetic variants in bone morphogenetic proteins signaling pathway might be involved in palatal rugae phenotype in humans.