Dec 25, 2024 · Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta.

SMAD4, also called SMAD family member 4, Mothers against decapentaplegic homolog 4, or DPC4 (Deleted in Pancreatic Cancer-4) is a highly conserved protein present in all metazoans. It belongs to the SMAD family of transcription factor proteins, which act as mediators of TGF-β signal transduction.

The SMAD4 gene provides instructions for making a protein involved in transmitting chemical signals from the cell surface to the nucleus. The SMAD4 protein is part of a signaling pathway, called the transforming growth factor beta (TGF-β) pathway, that allows the environment outside the cell to affect gene activity and protein production ...

smad4是肿瘤抑制因子，是 转化生长因子β-（tgfβ）信号通路的组成部分，参与细胞增殖、分化、迁移和凋亡，与基质炎症细胞间的相互作用，其缺失 可导致 胃肠道上皮性肿瘤 的发生，超过50%的家族性幼年息肉病（tps)携带smad4突变，易发生错构性息肉和胃肠道癌 ...

Co－Smad包括Smad4，是TGF-β家族各类 信号传导 过程中共同需要的介质。I－Smads包括Smad 6和Smad 7，可与激活的I型受体结合，抑制或调节TGF-β家族的 信号转导 。

Jan 12, 2018 · SMAD4, which serves as the central mediator of TGF-β signaling, is specifically inact … Transforming growth factor β (TGF-β) signaling pathway plays important roles in many biological processes, including cell growth, differentiation, apoptosis, migration, as well as cancer initiation and progression.

Jul 3, 2020 · Smad4 or DPC4 belongs to a family of signal transduction proteins that are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor beta (TGF-β) signaling via several pathways. The gene acts as a tumour suppressor gene and inactivation …

通用 Smad （ common Smad ， Co-Smad–Smad4 ） 磷酸化的R-Smad与Co-Smad/Smad4聚合并继续传递信号。 R-Smad与Smad4的聚合主要以异源三聚体的形式存在，并以二聚体的形式发挥作用，这可能与基因启动子区的结构有关。

Jun 18, 2021 · Mutations in SMAD4 (mostly substitutions) can cause Myhre syndrome, a rare inherited disorder characterized by mental disabilities, short stature, unusual facial features and various bone abnormalities (Am J Hum Genet 2012;90:161)

SMAD 家族成员 4： 该基因编码信号转导蛋白 Smad 家族的成员。 Smad 蛋白被跨膜丝氨酸-苏氨酸受体激酶磷酸化并激活，以响应转化生长因子 (TGF) -β 信号转导。该基因的产物与其他激活的 Smad 蛋白形成同源复合物和异源复合物，然后在细胞核中积累并调节靶基因的转录。这种蛋白质与 DNA 结合并识别 ...