SMAD3-knockout mouse is a legitimate animal model of human aneurysms‐osteoarthritis syndrome (AOS), also named Loeys-Dietz Syndrome (type 3). SMAD3 deficiency promotes inflammatory aortic aneurysms in angiotensin II-infused mice via the activation of iNOS.

2024年12月25日 · SMAD3 (SMAD Family Member 3) is a Protein Coding gene. Diseases associated with SMAD3 include Loeys-Dietz Syndrome 3 and Aortic Aneurysm. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and TGF-beta receptor signaling activates SMADs.

The SMAD3 gene provides instructions for making a protein involved in transmitting chemical signals from the cell surface to the nucleus. This signaling pathway, called the transforming growth factor-beta (TGF-β) pathway, allows the environment outside the cell to affect cell function, including how the cell produces other proteins.

2025年1月3日 · SMAD3 is a pivotal transcription factor that modulates the transforming growth factor-beta (TGF-β) signal and assumes a dual role in both restraining and promoting cancer. It features highly...

SMAD 蛋白家族是一组细胞内信号转导蛋白，类似于果蝇基因“母亲抗脑瘫” (Mad) 和秀丽隐杆线虫基因 Sma 的基因产物。 SMAD3 蛋白在转化生长因子-β信号通路中起作用，将信号从细胞表面传递到细胞核，调节基因活性和细胞增殖。 这种蛋白质与其他 SMAD 蛋白质形成复合物并结合 DNA，同时作为转录因子和肿瘤抑制因子发挥作用。 该基因的突变与动脉瘤-骨关节炎综合征和 Loeys-Dietz 综合征 3 有关。 [RefSeq 提供，2022 年 5 月]

2016年2月24日 · Smad2 and Smad3 are structurally similar and it is mostly considered that they are equally important in mediating TGFβ signals. Here, we show that Smad3 is an insensitive TGFβ transducer as...

The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor.

2023年3月31日 · The role of Smad3 in regulating neutrophil recruitment and polarization in lung cancer was investigated in wild-type (Smad3-WT) and Smad3-knockout (Smad3-KO) mice using the syngeneic Lewis...

5 天之前 · Intriguingly, SMAD3 positively transactivates PINK1 transcription independent of the canonical TGFβ signaling components, such as TGFβ-R1, SMAD2 or SMAD4. Second, we found that mitochondrial depolarization activates SMAD3 via PINK1-mediated phosphorylation of SMAD3 at serine 423/425. Therefore, PINK1 and SMAD3 constitute a positive ...

4 天之前 · smad3 促进线粒体自噬：由于 smad3 对 pink1 表达具有正向调控作用，研究人员进一步探究其对 pink1 依赖的线粒体自噬的影响。实验发现，smad3 抑制剂 e - sis3 预处理或 smad3 敲低，均显著减少了 o/a 诱导的线粒体蛋白（如 mfn1、coxiv 和 tomm20）降解，抑制了 parkin 向 …