SMAD2 Gene - GeneCards | SMAD2 Protein | SMAD2 Antibody
Dec 25, 2024 · SMAD2 (SMAD Family Member 2) is a Protein Coding gene. Diseases associated with SMAD2 include Loeys-Dietz Syndrome 6 and Congenital Heart Defects, Multiple Types, …
Smad2 and Smad3 have differential sensitivity in relaying TGFβ ...
Feb 24, 2016 · We conclude that Smad2 and Smad3 possess differential sensitivities in relaying TGFβ signaling and have distinct roles in regulating early developmental events.
The role of Smad signaling cascades in cardiac fibrosis - PMC
In vivo, fibroblast Smad3 signaling is critically involved in scar organization and exerts matrix-preserving actions. Although Smad2 also regulates fibroblast function in vitro, its in vivo role in …
SMAD2 SMAD family member 2 [ Homo sapiens (human) ]
Mar 4, 2025 · SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor …
The SMAD2/3 interactome reveals that TGFβ controls m 6 A mRNA ... - Nature
Feb 28, 2018 · The SMAD2 and SMAD3 protein interactome links TGFβ signalling to diverse effectors including m6A methyltransferase, which has a role in regulating differentiation of …
Regulation of Smad degradation and activity by Smurf2, an E3 …
Smurf2 selectively interacts with receptor-regulated Smads and preferentially targets Smad1 for ubiquitination and proteasome-mediated degradation. At higher expression levels, Smurf2 also …
Modeling SMAD2 Mutations in Induced Pluripotent Stem Cells …
Mar 3, 2025 · SMAD2 haploinsufficiency disrupts transcription factor binding and chromatin interactions critical for cardiovascular development. Differences between the molecular …
SUMOylation of Smad2 mediates TGF-β-regulated …
Smad2 is a signal transduction molecule downstream of the TGF-β family of receptors and plays a critical role in TGF-β signaling of epithelial cells (19, 20). TGF-β1 induces C-terminal …
Genome-wide mechanisms of Smad binding - PMC
In most cell types, TGF-β and activin induce phosphorylation of Smad2 and Smad3 (activin/TGF-β-specific R-Smads, or AR-Smads) and BMPs induce phosphorylation of Smad1, Smad5 and …
The Smad pathway - PubMed
In this review we will focus on proteins that modulate Smad activity, including SARA, for Smad Anchor for Receptor Activation, which functions during the initiation of signalling and on …
- Some results have been removed