2024年12月25日 · SLC5A7 (Solute Carrier Family 5 Member 7) is a Protein Coding gene. Diseases associated with SLC5A7 include Myasthenic Syndrome, Congenital, 20, Presynaptic …

The high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene. [5] It is a cell membrane transporter …

2025年2月8日 · Genetic analysis of a family affected by congenital myasthenic syndrome due to a Novel mutation in the SLC5A7 gene. Targeted demethylation of the SLC5A7 promotor inhibits …

SLC5A7/CHT1. CHT1 is a high-affinity Na + /choline transporter (K m = 2 μM), which is exclusively expressed in tissues containing cholinergic neurons. There, its transport activity …

2016年10月4日 · SLC5A7 is a Na(+)- and Cl(-)- dependent high-affinity transporter that mediates the uptake of choline for acetylcholine synthesis in cholinergic neurons (Apparsundaram et al., …

2025年2月8日 · Enables choline binding activity and choline transmembrane transporter activity. Involved in acetylcholine biosynthetic process and choline transport. Acts upstream of or within …

2023年11月23日 · Clinical resource with information about SLC5A7, Congenital myasthenic syndrome, Congenital myasthenic syndrome 20, Neuronopathy, distal hereditary motor, type …

SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials …

2022年1月28日 · Examination of the molecular mechanism reveals that SLC5A7 promotes p53 protein expression by directly interacting with and modifying p53 and disrupting the interaction …

2022年7月20日 · SLC5A7 (solute carrier family 5 member 7), also known as choline transporter 1 (CHT1), is downregulated in colorectal cancer (CRC) and functions as a tumor suppressor. …