2022年12月29日 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are …

Sirtuins are evolutionarily conserved nicotinamide adenine dinucleotide (NAD +)-dependent lysine deacylases or ADP-ribosyltransferases. These cellular enzymes are metabolic sensors …

Sirtuins are a family of seven SIRT enzymes found in the nucleus, cytoplasm, and mitochondria of human cells. These enzymes exist in nearly all species and perform many functions that are …

We review the status of Sirtuin-targeted drug discovery and development. Potent and selective pharmacological Sirt1 activators and inhibitors are available, and initial clinical trials have been …

2012年3月7日 · Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1–SIRT7) has received much attention for its regulatory role, mainly in …

Sirtuin is a nicotinamide adenine dinucleotide–dependent deacetylase. One of its isoforms, Sirt1, is a key molecule in glucose, lipid, and energy metabolism. The renal protective effects of Sirt1 …

2022年12月29日 · Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are …

Sirtuins are a group of proteins regulating many physiological functions and life processes. They have become an essential factor in research focused on aging processes as the deletion in the …

2016年5月25日 · Sirtuins are NAD + -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological …

2016年5月25日 · Sirtuins are NAD (+)-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological …