Sirtuin 7 - Wikipedia
NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene. [5][6][7] SIRT7 is member of the mammalian sirtuin family of proteins, which are …
SIRT7 Gene - GeneCards | SIR7 Protein | SIR7 Antibody
Dec 25, 2024 · SIRT7 (Sirtuin 7) is a Protein Coding gene. Diseases associated with SIRT7 include Lysosomal Storage Disease and Prostate Cancer. Among its related pathways are …
去乙酰化转移酶SIRT7的作用及机制研究进展
As a member of the Sirtuins family in mammals, SIRT7 locates in nucleus and is a highly specific H3K18Ac (acetylated lysine 18 of histone H3) deacetylase. Recent studies showed that SIRT7 …
SIRT7: a novel molecular target for personalized cancer …
Feb 21, 2024 · SIRT7 distinguishes itself as the exclusive mammalian Sirtuin primarily localized within the nucleolus, a crucial organelle involved in ribosome biogenesis. In this compartment, …
Structural basis of SIRT7 nucleosome engagement and substrate …
Feb 4, 2025 · Here, we report structures of nucleosome-bound SIRT7, and uncover the structural basis of its specificity towards H3K36 and K18 deacylation, combining a mechanism-based …
深圳大学刘宝华团队重磅综述：揭开衰老之谜的第七把钥匙
Sep 19, 2023 · SIRT7通过去乙酰化Fibrillarin和PAF53促进RNA polymerase I介导的rRNA的转录。SIRT7还可以直接去乙酰化U3-55k进而调控U3 snoRNA对18S rRNA的成熟加工过程。
SIRT7 is a histone desuccinylase that functionally links to …
Jul 20, 2016 · We show that SIRT7 is recruited to DNA double-strand breaks (DSBs) in a PARP1-dependent manner and catalyses desuccinylation of H3K122 therein, thereby promoting …
The seven faces of SIRT7 - PMC
SIRT7, a member of the sirtuin family of NAD +-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and …
长寿蛋白Sirtuins家族SIRT1到SIRT7，分别参与哪些生理过程？
sirt7能够支持心脏细胞功能，保护心肌细胞免受氧化应激和炎症损伤，延缓心脏因年龄增长而出现的退化。此外，sirt7还与dna修复相关，可以延长心脏细胞的寿命，帮助维持心血管系统的稳 …
SIRT7 is an RNA-activated protein lysine deacylase
Jan 1, 2017 · Mammalian SIRT7 is a member of the sirtuin family that regulate multiple biological processes including genome stability, metabolic pathways, stress responses, and …