2024年12月25日 · SEMA7A (Semaphorin 7A (JohnMiltonHagen Blood Group)) is a Protein Coding gene. Diseases associated with SEMA7A include Cholestasis, Progressive Familial Intrahepatic, 11 and Blood Group, John Milton Hagen System. Among its related pathways are Nervous system development and Semaphorin interactions.

2020年8月10日 · Endothelial to mesenchymal transition (EndMT) is an important pathological change in many diseases. Semaphorin7A (Sema7A) has been reported to regulate nerve and vessel homeostasis, but its...

2023年1月30日 · Semaphorin7a (SEMA7A), a membrane-anchored member of the semaphorin protein family, could be involved in a diverse range of immune responses via its receptor integrin β1.

Semaphorin 7A (SEMA7A) is a potent immunomodulator expressed in activated lymphocytes and myeloid cells. In this study, we show that SEMA7A is substantially upregulated on NK cells stimulated with cytokines, and specifically marks activated NK cells with a …

2017年12月21日 · Accumulating evidence suggests a role of semaphorins in vascular homeostasis. Here, we investigate the role of Sema7A (semaphorin 7A) in atherosclerosis and its underlying mechanism.

2003年7月24日 · Unlike many other semaphorins, which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic...

2021年3月2日 · Here, we identify the neuroimmune guidance cue Semaphorin 7A (Sema7A), which appears to link macrophage (MΦ) metabolic remodeling to inflammation resolution. Sema7A orchestrated MΦ chemotaxis and chemokinesis, activated MΦ differentiation and polarization toward the proresolving M2 phenotype, and promoted leukocyte clearance.

2017年3月10日 · Our data identify Sema7A as a key regulator of adult hippocampal neurogenesis, providing an example of how differential receptor usage spatiotemporally controls and diversifies the effects of...

2013年3月1日 · Sema7A regulates cell proliferation, differentiation, migration and maturation. The biological effects of Sema7A are mediated by plexinC1 and integrin receptors. Sema7A–plexinC1 and Sema7A–integrin interaction have opposing effects on cell adhesion. Abnormal expression and function of Sema7A is linked to disease and injury.

2025年2月8日 · Title: A Comprehensive Prognostic Analysis of Tumor-Related Blood Group Antigens in Pan-Cancers Suggests That SEMA7A as a Novel Biomarker in Kidney Renal Clear Cell Carcinoma. Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a.