The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein …

2024年12月25日 · SEC63 (SEC63 Homolog, Protein Translocation Regulator) is a Protein Coding gene. Diseases associated with SEC63 include Polycystic Liver Disease 2 With Or Without …

2017年4月28日 · In this article, we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that …

2004年5月9日 · We found that mutations in SEC63, encoding a component of the protein translocation machinery in the ER, also cause this disease. These findings are suggestive of a …

In this article, we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave first insights …

Here we report that inactivation of SEC63 induces an unfolded protein response (UPR) pathway that is protective against cyst formation. Specifically, using murine genetic models, we …

2024年12月10日 · Clinical resource with information about SEC63, Polycystic liver disease 2, and available tests. There are links to practice guidelines and authoritative resources like …

Collectively, the findings show that SEC63 function regulates IRE1α/XBP1 activation, SEC63 and XBP1 are required for GPS cleavage and maturation of PC1, and activation of XBP1 can …

2025年2月9日 · Mutations in SEC63 cause autosomal dominant polycystic liver disease, suggesting a role for cotranslational protein-processing pathways in maintaining epithelial …

2016年7月20日 · SEC63 works in concert with the SEC61 translocon (see 609213) and BIP (HSPA5; 138120) to facilitate cotranslational translocation across the endoplasmic reticulum …