Sec61, termed SecYEG in prokaryotes, is a membrane protein complex found in all domains of life. As the core component of the translocon, it transports proteins to the endoplasmic reticulum in eukaryotes and out of the cell in prokaryotes.

2023年5月11日 · Here we present near-atomic-resolution structures of human Sec61 inhibited by a comprehensive panel of structurally distinct small molecules—cotransin, decatransin, apratoxin, ipomoeassin,...

2017年11月1日 · Recently, cryoelectron tomography of translocons in native ER membrane vesicles, derived from human cell lines or patient fibroblasts, and even intact cells has given unprecedented insights into the architecture and dynamics of …

2017年4月28日 · In this article, we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave first insights...

2022年10月5日 · The Sec61 complex appears to be a good candidate to explain the mechanism of Ca 2+-store depletion associated with ER stress and UPR. The role of the Sec61 complex in cell death and ER stress has been investigated in the human cancerous cell line LNCaP (Hammadi et al., 2013).

These structural data are discussed in light of different Sec61 channel activities including ribosome receptor function, membrane insertion, and translocation of newly synthesized polypeptides as well as the putative physiological roles of the Sec61 channel as a passive ER calcium leak channel.

Sec61 is a eukaryotic homolog of the translocation channel SecYEG, which plays a crucial role in protein secretion and localization within cells. You might find these chapters and articles relevant to this topic.

2017年4月28日 · In this article, we review the current understanding of protein transport across the ER membrane as central function of Sec proteins and further focus on recent studies that gave first insights into the functional role and therapeutic relevance of Sec61, Sec62 and Sec63 in human diseases.

2023年1月3日 · The universally conserved protein-conducting channel Sec61 complex mediates core steps in these processes by translocating hydrophilic polypeptide segments of client proteins across the ER membrane and integrating hydrophobic transmembrane segments into …

The Sec61 channel consists of three subunits (Sec61α, Sec61β, Sec61γ in mammals; Sec61, Sbh1, Sss1 in yeast), two of which (Sec61 and Sss1) are essential in yeast (Mandon et al., 2013). The 10 transmembrane helices of Sec61 form the channel itself with a …