Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. [5] STAT proteins are key activators of gene transcription which bind to DNA in response to cytokine gradient. [6]

Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family and localizes to the cytoplasm. STAT4 is phosphorylated after a variety of cytokines bind to the membrane, and then dimerized STAT4 translocates to the nucleus to regulate gene expression.

2024年12月25日 · STAT4 (Signal Transducer And Activator Of Transcription 4) is a Protein Coding gene. Diseases associated with STAT4 include Disabling Pansclerotic Morphea Of Childhood and Systemic Lupus Erythematosus 11. Among its related pathways are Interleukin-12 family signaling and IL27-mediated signaling events.

STAT4 is a transcription factor that transduces interleukin-12, interleukin-23, and type I interferon cytokine signals in T cells and monocytes, leading to T-helper type 1 and T-helper type 17 differentiation, monocyte activation, and production of interferon-γ.

2000年5月25日 · In this review, we will focus on two STAT proteins, Stat6 and Stat4, which are activated specifically by IL-4 and IL-12, respectively. Both of these STATs have been found to be critical for the...

Signal transducer and activator of transcription 4 (STAT4) and STAT6 are key factors in the specification of helper T cells; however, their direct roles in driving differentiation are not well understood. Using chromatin immunoprecipitation and ...

2021年11月26日 · STAT4, STAT5, and STAT6 can be used as targets for ubiquitin-dependent destruction, while STAT1, STAT2, and STAT3 are more stable, indicating that the transcriptional active region also regulates...