2024年12月25日 · SSRP1 (Structure Specific Recognition Protein 1) is a Protein Coding gene. Diseases associated with SSRP1 include Lupus Erythematosus and Systemic Lupus Erythematosus. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and Gene expression (Transcription).

In this study, we investigated the potential role of SSRP1 in association with DNA repair mediated by homologous recombination (HR), one of the pathways involved in repairing replication-associated DNA damage, in mammalian cells.

In the formation of this complex, structure-specific recognition protein-1 (SSRP1) heterodimerizes with suppressor of Ty 16 (SPT16). SSRP1 also has SPT16-independent functions, but how SSRP1 functions alone remains elusive.

SSRP1 Is a Prognostic Biomarker Correlated with CD8 (+) T Cell Infiltration in Hepatocellular Carcinoma (HCC). CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC. The role of FACT in managing chromatin: disruption, assembly, or repair?

2020年3月12日 · Here, using Xenopus laevis, we show that SSRP1 stimulates replication origin assembly on somatic chromatin by promoting eviction of histone H1 through its N-terminal domain. Histone H1 removal...

We show that SSRP1 accumulates at SSBs in a PAR-dependent manner. How SSRP1 remains at damage sites by interacting with XRCC1 is shown based on a ALFFSRI RIR motif mediated interaction.

2015年12月21日 · Here, we report the crystal structure of the middle domain of SSRP1. It consists of tandem pleckstrin homology (PH) domains. These domains differ from the typical PH domain in that PH1 domain...

2018年6月29日 · In the formation of this complex, structure-specific recognition protein-1 (SSRP1) heterodimerizes with suppressor of Ty 16 (SPT16). SSRP1 also has SPT16-independent functions, but how SSRP1 functions alone remains elusive.

Title: SSRP1 Is a Prognostic Biomarker Correlated with CD8(+) T Cell Infiltration in Hepatocellular Carcinoma (HCC). CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC.

2024年12月10日 · Structure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis. SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway. Crystal Structure of Human SSRP1 Middle Domain Reveals a Role in DNA Binding.