Serine/arginine-Rich Splicing Factor (SRSF) protein kinase-1 SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene. [4][5][6] This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm.

2024年12月25日 · SRPK1 (SRSF Protein Kinase 1) is a Protein Coding gene. Diseases associated with SRPK1 include Denys-Drash Syndrome and Lung Cancer. Among its related pathways are Infectious disease and Translation of Structural Proteins. Gene Ontology (GO) annotations related to this gene include RNA binding and protein kinase activity.

2023年3月3日 · Serine-arginine protein kinase 1 (SRPK1) is a key oncoprotein in the EGFR/AKT pathway that participates in tumorigenesis. We found that high SRPK1 expression was...

2022年5月18日 · Serine-Arginine Protein Kinase 1 (SRPK1) is an enzyme which moderates the activity of splicing factors rich in serine/arginine domains. Here we review SRPK1’s relationship with various cancers by performing a systematic review of all relevant published data.

2018年12月8日 · SRPK1 is a serine/arginine protein kinase enzyme encoded by a gene located on chromosome 6 (6p21.31) in humans, specific for the SR family of splicing factors (serine/arginine-rich domain). SR proteins are long repeats of serine and arginine amino acid residues convoluted in splicing regulation via phosphorylation of SR splicing factors [1].

2022年10月27日 · Serine/arginine-rich protein kinase 1 (SRPK1), a key splicing regulator, is reported to be overexpressed in leukemia and other cancer types, which suggests the therapeutic potential of targeting SRPK1. SRPK1 expression was measured in 41 ENKTL patients by immunohistochemistry and mRNA expression was analyzed by qRT‒PCR.

Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3beta Ser9 autophosphorylation independent of its kinase activity in non-small-cell lung cancer. SRPK1 promotes sepsis-induced acute lung …

Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3beta Ser9 autophosphorylation independent of its kinase activity in non-small-cell lung cancer.

2020年5月27日 · Inhibiting SRPK1 activity or enhancing its acetylation re-sensitises cells to cisplatin, suggesting a potential strategy to treat cancers resistant to platinum-based therapy.

Serine/arginine protein kinase 1 (SRPK1); a versatile functional moonlighting protein involved in varied cellular activities comprised of cell cycle progression, innate immune response, chromatin reorganization, negative and positive regulation of viral …