Sterol regulatory element-binding protein - Wikipedia
A feature of the SREBP pathway is the proteolytic release of a membrane-bound transcription factor, SREBP. Proteolytic cleavage frees it to move through the cytoplasm to the nucleus. …
SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond
Insulin modulates the SREBP pathway through transcriptional and post-transcriptional mechanisms that emerge from the mTOR pathway. Modulation of the SREBP pathway …
SREBP transcription factors: master regulators of lipid …
Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid homeostasis by controlling the expression of a range of enzymes required for …
SREBP-regulated lipid metabolism: convergent physiology — …
Aug 29, 2017 · SREBP directly induces expression of oncogenic IDH1 and increases production of 2-hydroxyglutarate, a key oncometabolic regulator produced from glucose, which …
SREBP Regulation of Lipid Metabolism in Liver Disease, and …
SREBP-1c regulates transcription of genes involved in FAs, such as acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), two crucial DNL regulation enzymes, and triacylglycerol …
SREBP-regulated lipid metabolism: convergent physiology
Changes in cell metabolism and growth are reciprocally linked through SREBPs. Anabolic and growth signalling pathways branch off and connect to multiple steps of SREBP activation and …
SREBPs: activators of the complete program of cholesterol and …
The SREBPs play related but distinct roles: SREBP-1c, the predominant SREBP-1 isoform in adult liver, preferentially activates genes required for fatty acid synthesis, while SREBP-2 …
Sterol Regulatory Element Binding Protein - ScienceDirect
Sterol regulatory element binding protein (SREBP) is a membrane-bound transcription factor that regulates cellular lipogenesis and lipid homeostasis [281]. The correlation between SREBP …
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis ...
May 2, 1997 · In humans, hamsters, and mice, two members of the SREBP family, designated SREBP-1a and SREBP-1c, are produced from a single gene (human chromosomal location, …
Expanding Roles for SREBP in Metabolism - Cell Press
Oct 3, 2012 · Sterol regulatory element-binding protein (SREBP) transcription factors regulate cellular lipogenesis and lipid homeostasis.