PU.1 is an essential regulator of the pro-fibrotic system. In fibrotic conditions, PU.1 expression is perturbed in fibrotic diseases, resulting in upregulation of fibrosis-associated genes sets in fibroblasts. Disruption of PU.1 in fibrotic fibroblasts leads to them returning into their resting state from pro-fibrotic fibroblasts.

Dec 25, 2024 · SPI1 (Spi-1 Proto-Oncogene) is a Protein Coding gene. Diseases associated with SPI1 include Agammaglobulinemia 10, Autosomal Dominant and Autosomal Agammaglobulinemia. Among its related pathways are Gene expression (Transcription) and Assembly of the pre-replicative complex.

Salmonella pathogenicity island 1 (SPI-1) plays a crucial role in the interaction between Salmonella and host cells. SPI-1 promotes Salmonella invasion into epithelial cells (Raffatellu et al., 2005). The T3SS is assembled from the proteins encoded by SPI-1 …

Apr 16, 2020 · Salmonella Pathogenicity Island 1 (SPI-1) encodes a type three secretion system (T3SS), effector proteins, and associated transcription factors that together enable invasion of epithelial cells in animal intestines.

沙门菌毒力岛基因SPI-1和SPI-2分别编码Ⅲ型分泌系统 (T3SS)中的T3SS-1和T3SS-2,T3SS可以将沙门菌分泌的效应蛋白转运至宿主细胞中.为分析毒力岛基因SPI-1和SPI-2缺失对肠炎沙门菌生物学特性、致病性和免疫原性的影响,本实验室前期构建了肠炎沙门菌SM6株毒力岛基因SPI-1 ...

Spi-1 increases the speed of replication by acting specifically on elongation rather than enhancing origin firing. This review focuses on important protein-protein interactions of PU.1 that play a crucial role in regulation of normal as well as malignant haematopoiesis.

该基因编码一个 ETS 结构域转录因子，在骨髓和 B 淋巴细胞发育过程中激活基因表达。 核蛋白与靶基因启动子附近富含嘌呤的序列 PU-box 结合，并与其他转录因子和辅助因子协同调节它们的表达。 该蛋白质还可以调节靶基因的选择性剪接。 已发现该基因编码不同异构体的多个转录变体。 [RefSeq 提供，2008 年 7 月] This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development.

Aug 16, 2023 · 近期，浙江大学虞军团队在《中国神经再生研究（英文版）》（Neural Regeneration Research）上发表了题为“Spi1 regulates the microglial/macrophage inflammatory response via the PI3K/AKT/mTOR signaling pathway after intracerebral hemorrhage”的研究论文。 通过研究，作者发现，Spi1可以通过调节小胶质细胞和巨噬细胞的功能来调节脑出血后的神经炎症反应和神经功能恢复。 进一步研究表明,Spi1可能是通过调节PI3K/AKT/mTOR信号通路而改 …

Aug 4, 2023 · Spi-1原癌基因（SPI1）在致癌过程中发挥着至关重要的作用。 我们的工作旨在研究 SPI1 在黑色素瘤中的潜在调控机制。 通过 qRT-PCR 和蛋白质印迹法测量 mRNA 和蛋白质水平。 通过CCK-8测定评估细胞活力。

Jul 31, 2019 · The type III protein secretion system (T3SS) encoded by Salmonella pathogenicity island 1 (SPI-1) delivers effector proteins required for intestinal invasion and the production of enteritis.