Sox9, also known as SRY-Box Transcription Factor 9, is an important gene is sex determination. The SOX family of genes are all transcription factors for the Y chromosomal sex-determining factor SRY. The SRY gene encodes the SOX transcription factor while it upregulates Sox9.

The SOX9 gene provides instructions for making a protein that plays a critical role during embryonic development. The SOX9 protein is especially important for development of the skeleton and plays a key role in the determination of sex before birth.

2024年12月25日 · SOX9 (SRY-Box Transcription Factor 9) is a Protein Coding gene. Diseases associated with SOX9 include Campomelic Dysplasia and 46,Xx Sex Reversal 2. Among its related pathways are Gene expression (Transcription) and Mammalian disorder of …

In this review, we confine our discussion to one of the well-characterized SoxE proteins, Sox9. After discussing multiple levels of regulation and mechanisms, we review the versatile functions of Sox9 in germ layers and adult tissues as a stem cell regulator.

2025年3月8日 · Sox9 and Sex Determination: Plays a role in sex-specific gene expression in gonads. The SOX9 protein is a transcription factor that plays a crucial role in the development and function of the gonads, the reproductive organs. Its primary function is to regulate the expression of sex-specific genes, which are essential for the proper ...

SOX9 is a pivotal transcription factor in developing and adult cartilage. Its gene is expressed from the multipotent skeletal progenitor cells and is active throughout chondrocyte differentiation.

2023年7月24日 · Here we tackle this question with SOX9, a master regulator that diverts embryonic epidermal stem cells (EpdSCs) into becoming hair follicle stem cells. By engineering mice to re-activate SOX9...

LT and SOX9 expression are associated with gene sets that distinguish Merkel cell polyomavirus (MCPyV)-positive and MCPyV-negative Merkel cell carcinoma. SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys.

The SOX9 transcription factor controls the differentiation of many cell types among vertebrates. The SOX9 gene locus is large and complex and contains various tissue-specific enhancers. Individual enhancers direct specific expression of SOX9 in chondrocytes, Sertoli cells and cranial neural crest ce …

Wnt/β-catenin signaling requires inhibition of a multiprotein destruction complex that targets β-catenin for proteasomal degradation. SOX9 is a potent antagonist of the Wnt pathway and has been proposed to act through direct binding to β-catenin or the β-catenin destruction complex.