Transcription factor SOX-18 is a protein that in humans is encoded by the SOX18 gene. [5][6] This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate.

2024年12月25日 · SOX18 (SRY-Box Transcription Factor 18) is a Protein Coding gene. Diseases associated with SOX18 include Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome and Hypotrichosis-Lymphedema-Telangiectasia Syndrome. Among its related pathways is ERK Signaling.

2008年12月1日 · Here we use molecular, cellular and genetic assays in mice to show that Sox18 acts as a molecular switch to induce differentiation of lymphatic endothelial cells. Sox18 is expressed in a subset...

Natural mutations in the Sox18 gene have been shown to result in cardiovascular dysfunction, in some cases leading to death. Available evidence thus implicates Sox18 as an important regulator of vascular development, most likely playing a key role in endothelial cell specification.

2025年2月8日 · SOX18 promotes gastric cancer metastasis through transactivating MCAM and CCL7. A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development. Down-regulation of SOX18 inhibits laryngeal carcinoma cell proliferation, migration, and invasion through JAK2/STAT3 signaling.

SRY-related HMG-box 18 (SOX18) is an important transcription factor involved in angiogenesis, tissue injury, wound-healing, and in embryonic cardiovascular and lymphatic vessels development. The role of angiogenic transcription factors, SOX18 and the related, prospero homeobox 1 (PROX1) and chicken ovalbumin upstream promoter transcription ...

SOX18 is a transcription factor that plays a crucial role in lymphatic vascular development and is also involved in early blood vascular development. You might find these chapters and articles relevant to this topic. Natasha L. Harvey, in Heart Development and Regeneration, 2010.

2024年11月2日 · Title: A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity. Augmented angiogenic transcription factor, SOX18, is associated with asthma exacerbation.

2017年1月31日 · Sox18 is a transcription factor that first came to prominence more than a decade ago when it was discovered that mutations in the gene for Sox18 cause HLTS, a rare human condition that involves loss of hair, build up of lymph fluid …

The SOX18 gene (SRY-BOX Transcription Factor 18) (OMIM* 601,618) encodes a transcription factor in the SOX family, which is involved in the regulation of embryonic development and in the determination of the cell fate. From: European Journal of Medical Genetics, 2022