Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene. [5][6][7][8] This gene encodes a member of the SOX (SRY -related HMG-box) family of transcription factors involved in the regulation of embryonic development and …

2024年2月27日 · SOX10 is commonly expressed in peripheral nerves and melanomas with nerve cell involvement including desmoplastic melanoma. Answer A is incorrect because both benign nevi and melanomas can express SOX10, making it an insensitive marker for distinguishing between benign neoplasms and malignant melanomas.

SOX10 (Sry-related HMg-Box gene 10) is a key nuclear transcription factor in the differentiation of neural crest progenitor cells to melanocytes. It has been shown to be a sensitive and specific marker of malignant melanoma of multiple histologic types.

Expression of Sox10 in entrapped non-neoplastic Schwann cells or melanocytes in various neoplasms has to be considered in diagnosing Sox10-positive tumors. The Sox10 antibody belongs in a modern immunohistochemical panel for …

SOX10 belongs to a family of 20 SRY (sex-determining region Y)-related high mobility group box-containing (SOX) proteins, most of which contribute to cell type specification and differentiation of various lineages.

2024年12月25日 · SOX10 (SRY-Box Transcription Factor 10) is a Protein Coding gene. Diseases associated with SOX10 include Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease and Waardenburg Syndrome, Type 2E. Among its related pathways are Cell junction organization and MITF-M-dependent gene …

SOX10 plays a pivotal role in regulating melanocyte proliferation through its interaction with the minichromosomal maintenance complex component 5 (MCM5); Inducing overexpression of MCM5 in SOX10 knockout cells partially rescues the cell’s impaired proliferation capacity.