SK-BR-3 [SKBR3] cells were isolated from an adenocarcinoma patient treated with radiation, steroids, cytoxan, and 5-fluorouracil and can be used in breast cancer research.

The metastatic SKBR3 cell-membrane proteome revealed a broad and rich map of receptors, immune response, adhesion and transporter proteins that sustain cancer-cell interactions with the native or drug-altered tumor microenvironment.

Part of: ICBP43 breast cancer cell line panel. Part of: KuDOS 95 cell line panel. Part of: MD Anderson Cell Lines Project. From: Memorial Sloan Kettering Cancer Center; New York; USA. Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK 808. Population: Caucasian.

SK-BR-3 cells are breast cancer cells with high HER2 expression. HER2-positive breast cancer has a high rate of recurrence and metastasis, as well as poor prognosis (12). Finding anti-tumor drugs that can effectively inhibit the growth of SK-BR …

2022年6月27日 · Our work was aimed at exploring the cell-membrane proteome of a HER2+ breast-cancer cell line (SKBR3) to identify triggers responsible for uncontrolled cell proliferation and intrinsic resources that enable detection and therapeutic interventions.

SK-BR-3 is a human breast cancer cell line that overexpresses the Her2 (Neu/ErbB-2) gene product. These cells display an epithelial morphology in tissue culture and are capable of forming poorly differentiated tumors in immunocompromised mice. The SK-BR-3 cells and products derived from it are used often as positive controls in assays for Her2.

Trastuzumab was found to trigger autophagy in SKBR3 breast cancer cells that survived 72 h of high-dose treatment (Vazquez-Martin et al., 2009). Moreover, a sub line of trastuzumab-resistant SKBR3 cells was found to express higher levels of basal autophagy.

Cell Line: SK-BR-3, Established from pleural effusion tumor cells of a 43-year-old Caucasian female patient with breast adenocarcinoma.

Cell-membrane cellular subfractions of SKBR3/HER2+ breast cancer cells, used as a model system, were analyzed by high resolution mass spectrometry, and high-quality proteins (FDR<3%) identified by at least two unique peptides were …

2021年3月23日 · Conclusions: CMTM6 has an important function in HCC proliferation, migration, and invasion, via its interaction with and stabilization of vimentin. CMTM6 might represent a potential biomarker and therapeutic target to treat HCC. Keywords: CMTM6; EMT; HCC; Invasion; Migration; Proliferation.