Sirtuin 3 - Wikipedia
NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type information regulation 2 …
SIRT3: A Central Regulator of Mitochondrial Adaptation in Health …
SIRT3 is a NAD+-dependent deacetylase that regulates the function of numerous mitochondrial proteins with roles in metabolism, oxidative stress, and cell survival. It is emerging as an …
SIRT3 Gene - GeneCards | SIR3 Protein | SIR3 Antibody
Dec 25, 2024 · SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, …
Mitochondrial Sirtuin 3: New emerging biological function and ...
Jul 9, 2020 · Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably linked …
SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell ...
May 15, 2012 · SIRT3 is a member of the sirtuin family of protein deacetylases that is preferentially localized to mitochondria. Prominent among the proteins targeted by SIRT3 are …
SIRT3, a New Hope in Liver Diseases from Pathogenic …
SIRT3 alleviates liver diseases by regulating fatty acid metabolism, mitochondrial function, and immune-inflammatory response. Meanwhile, Withaferin A, lipoic acid, major royal jelly …
The role of SIRT3 in homeostasis and cellular health
Jun 25, 2024 · Citrate synthase (CS) is activated by SIRT3, promoting the condensation of acetyl-CoA with oxaloacetate to form citrate. SIRT3 deacetylates isocitrate dehydrogenase 2 (IDH2) …
SIRT3 - an overview | ScienceDirect Topics
SIRT3 is a mitochondrial sirtuin deacetylase that activates mitochondria functions and plays an important role in metabolism, oxidative stress, and cell survival (Giralt and Villarroya, 2012; …
The Role of SIRT3 in the Brain Under Physiological and …
SIRT3 influences oxidative phosphorylation and oxidative stress management. SIRT3 increases ETC efficiency by deacetylating and regulating the activities of mitochondrial complexes I, II, …
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3 ... - Nature
May 15, 2024 · Herein, we identified a new small-molecule activator of SIRT3 (named 2-APQC) by the structure-based drug designing strategy. 2-APQC was shown to alleviate isoproterenol …