Dec 25, 2024 · SETDB1 (SET Domain Bifurcated Histone Lysine Methyltransferase 1) is a Protein Coding gene. Diseases associated with SETDB1 include Huntington Disease and Hyperoxaluria, Primary, Type I. Among its related pathways are Regulation of endogenous retroelements and PKMTs methylate histone lysines.

May 5, 2021 · SETDB1 loss derepresses latent TE-derived regulatory elements, immunostimulatory genes, and TE-encoded retroviral antigens in these regions, and triggers TE-specific cytotoxic T cell...

SETDB1 immune functions include B cell maturation, T cell activity regulation, and immune escape in cancer cells. In B lymphocytes, SETDB1 mediates the transition from pro-B to pre-B cells and represses endogenous retroviruses (ERV) to encourage B cell lineage differentiation and maturation.

Aug 11, 2021 · The SET Domain Bifurcated Histone Lysine Methyltransferase 1 (SETDB1) is a prominent member of the Suppressor of Variegation 3-9 (SUV39)-related protein lysine methyltransferases (PKMTs), comprising three isoforms that …

Jul 3, 2024 · Our findings reveal that the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)-mediated H3K9me3, in conjunction with DNA methylation, restricts chromatin accessibility on a selective subset of SINEs in neural precursor cells.

Aug 2, 2024 · Chang et al. perform CRISPR-Cas9 library screens and identify SETDB1 and its binding partners as key players in suppressing the NK cell-mediated immune surveillance against acute myeloid leukemia with granulocytic and monocytic differentiation, highlighting SETDB1 as a selective and promising therapeutic target in this disease.

May 1, 2024 · SETDB1 is a crucial inhibitor of lung cancer at certain stages. SETDB1 coordinates with suppressor of mothers against decapentaplegic (SMAD)2/3 to form an inhibitory complex that suppresses lung cancer metastasis.

SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation. Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity. SETDB1 promotes gastric carcinogenesis and metastasis via upregulation of …

Jul 3, 2017 · We show that the SETDB1 repressor complex, which involves multiple KRAB zinc finger proteins, shields neuronal genomes from excess CTCF binding and is critically required for structural...

Jan 7, 2025 · This review explores SETDB1's dual function in immune regulation and tumor progression, emphasizing its potential in the development of innovative cancer treatments targeting epigenetic dysregulation and oncogenic signaling.