S100 calcium-binding protein B (S100B) is a protein of the S100 protein family. S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation.

2024年12月25日 · S100B (S100 Calcium Binding Protein B) is a Protein Coding gene. Diseases associated with S100B include Syringoma and Granular Cell Tumor . Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Interleukin-1 family signaling .

S100B is a useful neurobiochemical marker of brain damage such as in circulatory arrest, stroke and traumatic brain injury. S100B is also associated with neurodegenerative diseases like Alzheimer's disease or other chronic neurological diseases.

S100B belongs to a multigenic family of Ca 2+-binding proteins of the EF-hand type and is expressed in high abundance in the brain. S100B interacts with target proteins within cells thereby altering their functions once secreted/released with the multiligand receptor RAGE.

S100B has successfully been implemented in the clinic regionally (1) to screen mild TBI patients evaluating the need to perform a head computerized tomography, (2) to predict outcome in moderate-to-severe TBI patients, (3) to detect secondary injury development in brain-injured patients and (4) to evaluate treatment efficacy.

S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system. Its levels in biological fluids are recognized as a reliable biomarker of active neural distress, and more recently, mounting evidence points to S100B as a ...

S100B is a Ca 2+-binding protein mainly concentrated in astrocytes. Its levels in biological fluids (cerebrospinal fluid, peripheral and cord blood, urine, saliva, amniotic fluid) are recognized as a reliable biomarker of active neural distress.

S100B gene polymorphisms are associated with the S100B level and Alzheimer's disease risk by altering the miRNA binding capacity. Oxidative Stress and Serum S100B Levels in Adolescents with First-Episode Drug-Naive Unipolar Depression.

2023年7月20日 · S100B is a calcium-binding protein, widely expressed in the brain predominantly by astrocytes, but also by maturing oligodendrocytes, neural progenitor cells, dendritic cells and specific lymphocyte subpopulations. S100B can be released extracellularly and is considered as a marker of brain damage . Many studies have related S100B to a ...

S100 is not brain specific but can also be elevated following renal, liver, or gastrointestinal injury. S100B is more specific to brain tissue and has been shown repeatedly in adult studies of traumatic brain injury to be elevated, and to reflect the severity of injury.