Retinoid X receptor beta (RXR-beta), also known as NR2B2 (nuclear receptor subfamily 2, group B, member 2) is a nuclear receptor that in humans is encoded by the RXRB gene. [5] [6]This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic …

2024年12月25日 · RXRB (Retinoid X Receptor Beta) is a Protein Coding gene. Diseases associated with RXRB include Granulomatosis With Polyangiitis and Vasculitis. Among its related pathways are NR1H2 and NR1H3-mediated signaling and Gene expression (Transcription).

Gene ID: 6257, updated on 8-Feb-2025. This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA).

2025年2月8日 · Enables chromatin DNA binding activity and transcription cis-regulatory region binding activity. Involved in cellular response to retinoic acid. Acts upstream of or within several processes, including cardiac muscle tissue development; maternal placenta development; and positive regulation of transcription by RNA polymerase II.

2021年3月2日 · RXR interaction is necessary for NPM-RAR-mediated myeloid maturation arrest. Title: Interaction with RXR is necessary for NPM-RAR-induced myeloid differentiation blockade. A fatty acid-binding protein 7/RXRbeta pathway enhances …

2019年3月1日 · RXRA promotes cell cycle arrest, dopaminergic phenotype and neuritogenesis. RXRA restrains ERK1/2 overactivation. RXRB inhibits neuritogenesis. Retinoic acid (RA) promotes differentiation in multiple neurogenic cell types by promoting gene reprogramming through retinoid receptors and also by inducing cytosolic signaling events.

Network rewiring clearly characterizes the dynamic regulatory systems of distinct disease states. This study is the first to associate an RXRB-causal network with increased risks of nodal metastasis, tumor relapse, distant metastases and poor survival for oral cancer.

2000年8月31日 · HGNC Approved Gene Symbol: RXRB. Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38) : 6:33,193,588-33,200,853 (from NCBI) The retinoic acid receptors, alpha (RARA; 180240), beta (RARB; 180220), and gamma (RARG; 180190), require coregulators to bind effectively to response elements and target genes.

View mouse Rxrb Chr17:34250786-34257373 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

Homologous recombination in embryonic stem cells has been used to generate germline null mutations of the RAR- and RXR-coding genes in the mouse.