2024年12月25日 · RRBP1 (Ribosome Binding Protein 1) is a Protein Coding gene. Diseases associated with RRBP1 include Epithelioid Inflammatory Myofibroblastic Sarcoma and Flinders Island Spotted Fever. Among its related pathways are Signaling by ALK fusions and activated point mutants and Infectious disease.

RRBP1 is a membrane-bound protein found in the endoplasmic reticulum (ER). It was originally identified as the ribosome receptor for the ER, [5] however several groups later demonstrated that this activity did not co-fractionate with RRBP1 [6] [7] but rather with Sec61 (i.e. the translocon).

2015年7月21日 · Ribosome-binding protein 1 (RRBP1) has been implicated in the regulation of unfolded protein response, which is involved in almost every aspect of cancer development....

RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma by regulating Hippo pathway. Hypomethylated RRBP1 Potentiates Tumor Malignancy and Chemoresistance in Upper Tract Urothelial Carcinoma. Correlation between reticulum ribosome-binding protein 1 (RRBP1) overexpression and prognosis in cervical squamous cell carcinoma.

该基因编码内质网 (ER) 膜的核糖体结合蛋白。 研究表明，该基因在 ER 增殖、分泌途径和分泌细胞分化以及 ER-微管相互作用的介导中发挥作用。 已经观察到选择性剪接，并且蛋白质同种型的特征在于 N 末端十肽和 C 末端七肽重复区域。 串联重复的剪接导致核糖体结合亲和力和分泌功能的变化。 重复长度不同的变体的全长性质尚未确定。 该基因的假基因已在 3 号和 7 号染色体上被鉴定出来，并且 RRBP1 已被排除在导致 Alagille 综合征的候选基因之外，这是 20p12 号染色体 …

2024年12月10日 · Title: Endoplasmic reticulum ribosome-binding protein 1, RRBP1, promotes progression of colorectal cancer and predicts an unfavourable prognosis. Data indicate that p180 is required for the efficient targeting of placental alkaline phosphatase (ALPP) mRNA to the endoplasmic reticulum (ER).

2015年9月1日 · Ribosome-binding protein 1 (RRBP1) has been implicated in the regulation of unfolded protein response, which is involved in almost every aspect of cancer development. We aimed to explore the significance of RRBP1 in the progression and prognosis of …

2013年10月10日 · Ribosome-binding protein 1 (RRBP1) was originally identified as a ribosome-binding protein located on the rough ER and associated with unfolding protein response (UPR). In this report, we investigated the role of RRBP1 in lung cancer.

2021年3月24日 · Genetic (knockout) or pharmacological (Radezolid, represses expression of RRBP1) inhibition of RRBP1 restores cisplatin-mediated cell death in chemo-resistant OSCC. Mechanistically, RRBP1...

2013年1月14日 · Ribosome-binding protein 1 (RRBP1) was originally identified as a ribosome-binding protein located on the rough ER and associated with unfolding protein response (UPR)....