Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene. [5] [6] [7] The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.

Dec 25, 2024 · This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and plays a key role in DNA replication and repair. Alternate in-frame start codon initiation results in the production of alternate isoforms that …

Sep 1, 2022 · 真核RNase H1则具有N端线粒体靶向序列 (MTS)，该蛋白以两种亚型表达，分布定位于细胞核和线粒体。 此外，真核RNase H1还包含一个额外靠近N端的约50个氨基酸区域，称为杂合结合域（hybrid binding domain, HBD）。 在几种细菌（Shewanella sp. SIB1和 Bacillus halodurans）中也发现了具有杂合结合域的RNase H1。 HBD通过RNase H1活性所需的自由接头连接到C端催化结构域 上。 该接头区域在序列和长度方面是物种中最不保守的（从 B. …

RNase H1 has become an essential tool to uncover the physiological and pathological roles of R-loops, three-stranded structures consisting of and RNA-DNA hybrid opposite to a single DNA strand (ssDNA). RNase H1 degrades the RNA portion of the R-loops returning the two DNA strands to double-stranded form (dsDNA).

核糖核酸酶 H1： 该基因编码一种核酸内切酶，可特异性降解 RNA-DNA 杂交体的 RNA，并在 DNA 复制和修复中发挥关键作用。 交替的框内起始密码子起始导致产生指向线粒体或细胞核的交替同种型。 线粒体亚型的产生由上游开放阅读框 (uORF) 调节。 在具有线粒体 DNA 缺失、常染色体隐性遗传 2 的进行性眼外肌麻痹患者中发现了该基因的突变。 可变剪接导致额外的编码和非编码转录物变异。 该基因的假基因已在 2 号和 17 号染色体上定义。 [RefSeq 提供，2017 年 7 月]

Feb 9, 2025 · RPA is a sensor of R loops and a regulator of RNaseH1, extending the versatile role of RPA in suppression of genomic instability. RNaseH1 maintains regulated levels of telomeric RNA-DNA hybrids at ALT telomeres to trigger homologous recombination without compromising telomere integrity too severely

Feb 9, 2025 · RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells. Arora R, et al. Nat Commun, 2014 Oct 21. PMID 25330849, Free PMC Article. What's a GeneRIF? RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis.

RNase H1 is present in prokaryotes and eukaryotes and cleaves RNA in RNA/DNA hybrids. Its main function is hybrid removal, notably in the context of R-loops. RNase H2, which is also present in all branches of life, can play a similar role but it also has a specialized function in the cleavage of single ribonucleotides embedded in the DNA.

Dec 1, 2019 · RNase H1 is present in prokaryotes and eukaryotes and cleaves RNA in RNA/DNA hybrids. Its main function is hybrid removal, notably in the context of R-loops. RNase H2, which is also present in all branches of life, can play a similar role but it also has a specialized function in the cleavage of single ribonucleotides embedded in the DNA.

Our studying suggests that RNASEH1 is a potential cancer biomarker. And RNASEH1 may be able to regulate the tumor microenvironment by regulating the relevant physiological activities of mitochondrial and thereby regulating the occurrence and development of tumors.