Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene. [5] [6] [7] This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases.

Dec 25, 2024 · RIPK2 (Receptor Interacting Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases associated with RIPK2 include Crohn's Disease and Leprosy. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and SARS-CoV-2 Infection.

Aug 21, 2018 · Receptor-interacting protein (RIP) kinases, in particular RIPK1, RIPK2 and RIPK3, have emerged as pleiotropic modulators of inflammatory responses that act either by directly regulating...

Feb 3, 2022 · Here we show receptor-interacting protein kinase 2 (RIPK2) is a clinically actionable target for inhibiting PC metastasis. RIPK2 is amplified/gained in ~65% of lethal metastatic...

Nov 5, 2023 · RIPK2 is an upstream regulator of stress-induced caspase-1 activation, which is essential for neuronal death induced by overexpression of RIPK2 [29]. Therefore, RIPK2 is considered as a novel therapeutic target of ALS and HD.

Apr 14, 2021 · Receptor-interacting serine/threonine kinase 2 (RIPK2), also known as receptor-interacting protein 2 (RIP2), is a downstream signaling molecule for nucleotide-binding oligomerization domain 1 (NOD1), NOD2, and Toll-like receptors (TLRs).

Feb 8, 2024 · Through in vivo CRISPR screen, we identified that RIPK2 plays a crucial role in facilitating immune evasion by impeding antigen presentation and cytotoxic T-cell killing. Targeting tumor-intrinsic RIPK2 either genetically or pharmacologically improves PDAC to anti-PD-1 immunotherapy.

Nov 5, 2023 · The present study reviews the molecule structure and biological functions of RIPK2, and its correlation between human diseases. In addition, we focus on the structure-activity relationship of small molecule inhibitors of RIPK2 and their therapeutic potential in …

As an essential mediator of inflammation and innate immunity, the receptor-interacting serine/threonine-protein kinase-2 (RIPK2) is responsible for transducing signaling downstream of the intracellular peptidoglycan sensors nucleotide ...

Sep 30, 2023 · Receptor-interacting protein kinase 2 (RIPK2) is a serine/threonine kinase whose activity propagates inflammatory signaling through its association with pattern recognition receptors (PRRs) and subsequent TAK1, NF-κB, and MAPK pathway activation.