2014年12月15日 · We propose rules for estimating the risks associated with genes that are present in environmental resistomes by evaluating the likelihood of their introduction into human pathogens, and the...

Apparently most pathogenic microorganisms have the capability of developing resistance to at least some antimicrobial agents. The main mechanisms of resistance are: limiting uptake of a drug, modification of a drug target, inactivation of a drug, and active efflux of a drug.

2022年3月23日 · Antibiotic resistance genes (ARGs) have accelerated microbial threats to human health in the last decade. Many genes can confer resistance, but evaluating the relative health risks of ARGs is...

The origin and molecular basis of bacterial resistance is the presence of antibiotic resistance genes (ARGs). Investigations on ARGs mostly focus on the environments in which antibiotics are frequently used, such as hospitals and farms.

In this review an overview is given on antibiotic resistance (AR) mechanisms with special attentions to the AR genes described so far preceded by a short introduction on the discovery and mode of action of the different classes of antibiotics.

Welcome to the NCBI National Database of Antibiotic Resistant Organisms (NDARO), a collaborative, cross-agency, centralized hub for researchers to access AMR data to facilitate real-time surveillance of pathogenic organisms. From left to right: Multi-drug resistant Salmonella enterica, kpc2 carbapenem resistance gene.

2023年3月8日 · Bacterial communities in humans, animals, and the external environment maintain a large collection of antibiotic resistance genes (ARGs). However, few of these ARGs are well-characterized and thus established in existing resistance gene databases.

2021年3月1日 · Researchers have long known that naturally occurring antibiotic resistance genes (ARGs) can transfer between microbial species, disrupting clinical or veterinary antibiotic use.

Emergence of antibiotic resistant pathogenic bacteria poses a serious public health challenge worldwide. However, antibiotic resistance genes are not confined to the clinic; instead they are widely prevalent in different bacterial populations in the environment.

2025年1月10日 · Antimicrobial resistance (AMR) poses a threat to global health, as it undermines our ability to treat infectious diseases effectively. The spread of AMR is largely driven by the transfer of resistance genes among bacteria, enabling them to survive antibiotic treatments that once eradicated infections.