RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme [4] that in humans is encoded by the RAF1 gene. [5] [6] The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases. [7]

Dec 25, 2024 · RAF1 (Raf-1 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with RAF1 include Leopard Syndrome 2 and Noonan Syndrome 5. Among its related pathways are Prolactin Signaling and IL-9 Signaling Pathways.

一旦被激活，细胞 RAF1 蛋白可以磷酸化以激活双重特异性蛋白激酶 MEK1 和 MEK2，后者又磷酸化以激活丝氨酸/苏氨酸特异性蛋白激酶 ERK1 和 ERK2。 激活的 ERK 是细胞生理学的多效效应子，在控制细胞分裂周期、细胞凋亡、细胞分化和细胞迁移中涉及的基因表达方面发挥重要作用。 该基因的突变与 Noonan 综合征 5 和 LEOPARD 综合征 2 有关。 [RefSeq 提供，2008 年 7 月] …

RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. [11] . The mouse sarcoma virus 3611 contains a RAF kinase-related oncogene that enhances fibrosarcoma induction. RAF is an acronym for R apidly A ccelerated F ibrosarcoma. [12]

RAF1，即丝裂原活化蛋白激酶激酶1，别名CRAF、Raf-1、Raf激酶等。 它是一种由RAF1基因编码的蛋白激酶，属于RAF家族成员，在多种细胞类型中表达。 RAF1的作用机制涉及作为丝裂原活化蛋白激酶（MAPK）信号通路中的一个关键调节因子，通过磷酸化并激活下游的MEK1/2 ...

Sep 2, 2022 · 除了开发对抗KRAS的药物外，目前该领域最活跃的研究之一是寻求识别蛋白质的抑制剂，如RAF1，其负责传递KRAS致癌信号的蛋白质。 2020年，CNIO团队使用了一种小鼠模型，准确地再现了人类疾病，通过激活KRAS癌基因并停用p53肿瘤抑制因子来诱导侵袭性肺肿瘤，p53肿瘤抑制因子是导致高百分比人类肺腺癌的遗传组合。 然后，一旦肿瘤形成，基因就会 …

The RAF1 gene mutations change single protein building blocks (amino acids) in the RAF1 protein. These changes increase protein activity and disrupt the regulation of the RAS/MAPK signaling pathway causing problems with cell division, apoptosis, cell …

Dec 18, 2023 · CRAF (RAF1), a member of the RAF kinase family, is an effector of RAS signaling that was first discovered in 1988. CRAF contributes to RAS signaling and exhibits an array of kinase-dependent and kinase-independent activities. A comprehensive understanding regarding the implication of aberrant CRAF activity in tumors remains unclear.

与人 RAF1 同源（Raf-1 原癌基因，丝氨酸/苏氨酸激酶）。 [由基因组资源联盟提供，2022 年 4 月] Enables several functions, including ATP binding activity; Adenylate Cyclase Activator activity; and Enzyme binding activity.

RAF原癌基因丝氨酸/苏氨酸 - 蛋白激酶，也称为原癌基因c-RAF或简称c-Raf或甚至Raf-1，是一种酶，在人类中由RAF1基因编码。 c-Raf蛋白是ERK1 / 2途径的一部分，作为MAP激酶激酶激酶（MAP3K），其功能在膜相关GTP酶的Ras亚家族的下游。