RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme [4] that in humans is encoded by the RAF1 gene. [5] [6] The c-Raf protein is part of the ERK1/2 pathway as a MAP kinase (MAP3K) that functions downstream of the Ras subfamily of membrane associated GTPases. [7]

This is a Form to be completed for claims for compensation under section 17 of the Road Accident Fund Act as prescribed in section 24(1)(a) and regulation 7. This Form must be completed in its full particulars and in instances where there are asterisks indicating that supporting documents will be required, such must be included for completeness.

The RAF 1 is a British air-cooled, V-8 engine developed for aircraft use during World War I. Based on a French design, it was developed at the Royal Aircraft Factory, and built by six different British companies including Daimler, Rolls-Royce and Wolseley Motors Limited.

The RAF1 gene provides instructions for making a protein that is part of a signaling pathway called the RAS/MAPK pathway, which transmits chemical signals from outside the cell to the cell's nucleus.

2024年12月25日 · RAF1 (Raf-1 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with RAF1 include Leopard Syndrome 2 and Noonan Syndrome 5. Among its related pathways are Prolactin Signaling and IL-9 Signaling Pathways.

The kinase-defective Raf-1 mutants Raf-1 K375M and Raf-1 S259/621A were capable of binding ASK1 (Fig. 3D). We examined whether the catalytic activity of Raf-1 was required for inhibiting ASK1-induced cell death in HeLa cells.

2025年2月20日 · Title: Cross-Talking Pathways of Rapidly Accelerated Fibrosarcoma-1 (RAF-1) in Alzheimer's Disease. Molecular analyses of the C-terminal CRAF variants associated with cardiomyopathy reveal their opposing impacts on the active conformation of the kinase domain.

2005年1月21日 · The Raf-1 kinase is an important signaling molecule, functioning in the Ras pathway to transmit mitogenic, differentiative, and oncogenic signals to the downstream kinases MEK and ERK. Because of its integral role in cell signaling, Raf-1 …

Raf-1 kinase has gained much attention due to its function as a critical shuttle enzyme that connects stimulation of growth factor receptors and protein kinase C at the cell membrane to changes in the expression of genes involved in the control …

2025年2月9日 · Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells. Two cases of LEOPARD syndrome--RAF1 mutations firstly described in children.