Malignant cells use ROR1 expression to promote survival, proliferation and migration, processes normally active in embryonic cells, but redirected by cancer cells to support tumor growth and metastasis. ROR1 supports tumor cell survival by inhibiting apoptosis, while its overexpression drives uncontrolled proliferantion [4–6].

Jun 15, 2017 · ROR1 is considered a promising target for cancer therapy due to putative tumor-specific expression, and multiple groups are developing antibodies and/or chimeric antigen receptor-modified T cells to target ROR1.

Dec 25, 2024 · ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) is a Protein Coding gene. Diseases associated with ROR1 include Deafness, Autosomal Recessive 108 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are GPCR Pathway and ERK Signaling.

Oct 12, 2021 · Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein present on many cancers. Zilovertamab vedotin (ZV) is an antibody–drug conjugate comprising a monoclonal...

5 days ago · MSD starts pivotal trial of ROR1 drug in first-line lymphoma. MSD has started a phase 3 trial of ROR1-directed ADC zilo-V as a treatment for previously untreated diffuse large B-cell lymphoma.

Aug 13, 2024 · Overexpression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) contributes to cancer cell proliferation, survival and migration, playing crucial roles in tumor development. ROR1 has been proposed as a potential therapeutic target for cancer treatment.

May 24, 2024 · Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the type I receptor tyrosine kinase family. ROR1 is pivotal in embryonic development and cancer, and serves as a biomarker and therapeutic target.

Mar 10, 2025 · IM-1021 is an optimized, ROR1-targeted ADC that incorporates Immunome’s proprietary TOP1 inhibitor, HC74. The Phase 1 trial is an open-label, multicenter dose escalation and expansion study ...

Oct 6, 2022 · Since its initial identification in 1992 as a possible class 1 cell-surface receptor without a known parent ligand, receptor tyrosine kinase–like orphan receptor 1 (ROR1) has stimulated research, which has made apparent its significance in embryonic development and …

Nov 5, 2024 · ROR1 is an oncoembryonic pseudo-tyrosine kinase receptor expressed on malignant cells across a variety of hematologic and solid malignancies. As such, ROR1 is an ideal therapeutic target with potential for maximizing on-target anti …