Ribonuclease P (EC 3.1.26.5, RNase P) is a type of ribonuclease which cleaves RNA. RNase P is unique from other RNases in that it is a ribozyme – a ribonucleic acid that acts as a catalyst in the same way that a protein -based enzyme would.

Nuclease P1 is a zinc-dependent single-strand specific nuclease which hydrolyzes phosphodiester bonds in RNA and ssDNA with no base specificity. Nuclease P1 also exhibits 3′-phosphomonoesterase activity (1).

We outline early works on human RNase P as a tRNA processing enzyme and comment on its expanding nonconventional functions in molecular networks of transcription, chromatin remodeling, homology-directed repair, and innate immunity.

核酸酶 p1 是一种锌依赖的单链特异性核酸酶，能无碱基特异地水解 rna 和单链 dna（ssdna）上的磷酸二酯键。 核酸酶 P1 还具有 3′-磷酸单酯酶活性（1）。

RNase P is an essential enzyme that catalyzes removal of the 5′ leader from precursor transfer RNAs. The ribonucleoprotein (RNP) form of RNase P is present in all domains of life and comprises a single catalytic RNA (ribozyme) and a variable number of protein cofactors.

Ribonuclease P (RNase P) is an ancient and essential endonuclease that catalyses the cleavage of the 5′ leader sequence from precursor tRNAs (pre-tRNAs). The enzyme is one of only two ribozymes which can be found in all kingdoms of life (Bacteria, Archaea, and Eukarya).

The composition of Buffer P1 is: 50 mM Tris·Cl, pH 8.0; 10 mM EDTA; 100 µg/ml RNase A; After RNase A addition, the buffer should be stored at 2–8°C. Buffer P1 is the resuspension buffer used in a variety of QIAGEN kits for plasmid DNA purification.

2024年2月12日 · RNase P is recruited to DNA DSBs and represses H3.3 recruitment to actively transcribed genes. RPP21 and RPP29 are recruited to DNA DSBs by binding to PAR moieties, while H1 RNA may provide a potential platform for the …

We outline early works on human RNase P as a tRNA processing enzyme and comment on its expanding nonconventional functions in molecular networks of transcription, chromatin remodeling, homology-directed repair, and innate immunity.

RNase P is an essential enzyme that catalyzes removal of the 5′ leader from precursor transfer RNAs. The ribonucleoprotein (RNP) form of RNase P is present in all domains of life and comprises a single catalytic RNA (ribozyme) and a variable number of protein cofactors.