RIPK1 is an enzyme that in humans is encoded by the RIPK1 gene, which is located on chromosome 6. [6][7][8] This protein belongs to the Receptor Interacting Protein (RIP) kinases …

We discuss the current understanding of RIPK1 regulatory mechanisms and emerging evidence for the pathological roles of RIPK1 in human diseases, especially in the context of the central …

Dec 25, 2024 · Complete information for RIPK1 gene (Protein Coding), Receptor Interacting Serine/Threonine Kinase 1, including: function, proteins, disorders, pathways, orthologs, and …

Jul 15, 2020 · Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a master regulator of the cellular decision between pro-survival NF-κB signalling and death in response …

Aug 20, 2020 · This article reviews RIPK1 biology and disease-associated mutations in RIPK1 signalling pathways, highlighting clinical trials of RIPK1 inhibitors and potential strategies to …

Members of the Receptor Interacting Protein Kinases (RIPKs) family are key regulators of cell death and inflammation. Recent studies showed that RIPK1 is a pleiotropic cell death adaptor …

Aug 11, 2023 · Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is emerging as a critical stress sentinel that functions as a molecular switch, governing cellular survival,...

RIPK1 serves as the central player in cell death signal transduction, overseeing the activation of NF-κB pathway, apoptosis and necroptosis. Of the various cell necrosis mechanisms, the …

Feb 21, 2025 · ZBP1 is known to initiate RIPK3-mediated necroptosis in murine models of viral infection, but how this pathway is regulated in human cells is unclear. This study shows that, …

May 23, 2024 · Mannion et al. describe the development of a RIPK1-selective PROTAC degrader that boosts the immunostimulatory and antitumor activity of radiotherapy (RT) and immune …