In humans, RAD51 is a 339- amino acid protein that plays a major role in homologous recombination of DNA during double strand break repair. In this repair process, an ATP …

RAD51 is an ATPase that forms a nucleoprotein filament on single-stranded DNA. RAD51 has the function of finding and invading homologous DNA sequences to enable accurate and timely …

Rad51 serves as a key regulator for proper HRR to ensure DNA repair. Besides, Rad51 also participates in the tumor metabolism, metastasis and chemotherapeutic resistance. Rad51 …

2024年12月25日 · RAD51 (RAD51 Recombinase) is a Protein Coding gene. Diseases associated with RAD51 include Fanconi Anemia, Complementation Group R and Breast Cancer. Among …

As the primary catalyst of homologous recombination (HR) in vertebrates, RAD51 has been extensively studied in the context of repair of double-stranded DNA breaks (DSBs). With …

2024年3月20日 · RAD51 is the central eukaryotic recombinase required for meiotic recombination and mitotic repair of double-strand DNA breaks (DSBs) 1, 2. However, the mechanism by …

2023年6月21日 · Here we used cryo-electron microscopy, AlphaFold2 modelling and structural proteomics to determine the structure of the RAD51B–RAD51C–RAD51D–XRCC2 complex …

2021年9月10日 · In this study, we show that RAD51 protects under-replicated DNA in mitotic human cells and, in this way, promotes mitotic DNA synthesis (MiDAS) and successful …

2023年2月10日 · RAD51 is a highly conserved recombinase which serves crucial functions in the cell through its role in DNA damage repair (homologous recombination, HR) and in replication …

2020年9月25日 · RAD51 is central to DNA damage repair in the HR pathway. As such, understanding the function and regulation of RAD51 is essential for cancer biology. This …