Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the ...
Pyk2 colocalizes and interacts with tau in neurons. The in vivo evidence of a role of Pyk2 in tau pathology led us to investigate the association of Pyk2 and tau in more detail, including under …
PTK2B - Wikipedia
Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene. [5][6] This gene encodes a cytoplasmic protein tyrosine kinase that is involved in calcium-induced …
Frontiers | The Non-receptor Tyrosine Kinase Pyk2 in Brain ...
Pyk2 is a non-receptor tyrosine kinase highly enriched in forebrain neurons. Pyk2 is closely related to focal adhesion kinase (FAK), which plays an important role in sensing cell contacts …
Role of Pyk2 in Human Cancers - PubMed
2018年11月14日 · Pyk2 serves as a non-receptor tyrosine kinase regulating tumor cell survival, proliferation, migration, invasion, metastasis, and chemo-resistance, and is associated with …
PYK2 senses calcium through a disordered dimerization and ...
2022年8月9日 · Here, we investigated the mechanism by which the protein tyrosine kinase 2-beta (PYK2) functions as a sensor and effector of cellular calcium influx. We show that the linker …
PYK2, a hub of signaling networks in breast cancer progression
2024年4月1日 · PYK2 functions as a signaling hub in various cascades, and its involvement in positive and negative feedback loops enhances signaling robustness, modulates signaling …
Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the ...
The protein tyrosine kinase Pyk2 is encoded by PTK2B, a novel Alzheimer's disease (AD) susceptibility variant, with the PTK2B risk allele being associated with increased mRNA levels, …