2021年12月1日 · This study explored the novel immune checkpoint poliovirus receptor-related immunoglobulin domain-containing (PVRIG) in acute myeloid leukemia (AML). We showed that AML patient blasts consistently expressed the PVRIG ligand (poliovirus receptor-related 2, …

Poliovirus receptor related immunoglobulin domain containing is a protein that in humans is encoded by the PVRIG gene. [5]

2021年9月10日 · An emerging co-inhibitory receptor, CD112R (also called PVRIG), is most commonly expressed on natural killer (NK) and T cells. It binds to its ligand (CD112 or PVRL2/nectin-2) and inhibits the strength with which T cells and NK cells respond to cancer.

2024年7月2日 · Using spatial and single-cell RNA transcriptomics data across diverse cancer indications, we found that among the T-cell checkpoints, PVRIG is uniquely expressed on TSCM and PVRL2 is expressed on DCs in immune aggregate niches in tumors.

PVRIG is a recently identified immune checkpoint receptor and blockade of which could reverse T cell exhaustion to treat murine tumor; however, its therapeutic potential via NK cells in mice and human remains seldom reported.

PVRIG expression is induced on T and NK tumor infiltrating cells, whereas PVRL2 is expressed on tumor, endothelial and myeloid cells in the tumor micro-environment (TME). 3 We investigated the expression of PVRIG and PVRL2 across TME immune subpopulations.

2023年1月10日 · Among all members of the TIGIT/DNAM-1 axis, PVRIG expression was higher in tumors than in normal liver, was heterogeneous across tumors, and was the only member with independent prognostic value for better survival.

2025年2月8日 · PVRIG is a novel NK cell immune checkpoint receptor in acute myeloid leukemia. we demonstrate that PVRIG and PVRL2 are expressed in human cancers and the PVRIG-PVRL2 and TIGIT-PVR pathways are nonredundant inhibitory signaling pathways.

2020年10月29日 · CD112R, also known as poliovirus receptor-related immunoglobulin domain protein (PVRIG), is a newly identified inhibitory checkpoint receptor in the PVR-like family.

Poliovirus receptor-related immunoglobulin domain-containing (PVRIG) has recently been identified as an immune checkpoint molecule with potential for therapeutic development. 1 In humans, PVRIG is expressed on T cells (predominantly CD8 + T cells) and natural killer (NK) cells, but not on B cells, monocytes or neutrophils. 1 PVRIG binds to a sin...