The Von Hippel–Lindau tumor suppressor also known as pVHL is a protein that, in humans, is encoded by the VHL gene. Mutations of the VHL gene are associated with Von Hippel–Lindau …

2008年6月17日 · In general, pVHL acts as a multipurpose adaptor protein that controls a diverse array of gene expression programs, as well as extracellular matrix assembly and microtubule …

2014年12月23日 · VHL tumour suppressor protein (pVHL) plays a key part in cellular oxygen sensing by targeting hypoxia-inducible factors for ubiquitylation and proteasomal degradation.

Patients with germ line mutations in the von Hippel-Lindau (VHL) tumor suppressor are affected by a rare familial tumor syndrome, which is characterized by the predisposition to develop …

Functional inactivation of pVHL is causative of the von Hippel–Lindau disease, an inherited predisposition to develop different cancers. Due to its impact on human health, pVHL has …

von Hippel–Lindau (VHL) disease is a rare, autosomal dominant genetic disorder characterized by the development of multiple tumors and cysts throughout the body, resulting from germline …

2008年1月25日 · Germ-line mutations in the von Hippel–Lindau tumor (VHL) suppressor can be found in patients with VHL disease, a rare familial tumor syndrome characterized by the …

2011年3月9日 · von Hippel–Lindau (VHL) disease (MIM Number 193300) is an autosomal dominantly inherited neoplastic disorder that demonstrates marked phenotypic variability and …

In general, pVHL acts as a multipurpose adaptor protein that controls a diverse array of gene expression programs, as well as extracellular matrix assembly and microtubule-based …

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