Dec 25, 2024 · PRKAA1 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) is a Protein Coding gene. Diseases associated with PRKAA1 include Mitochondrial Disease and Wolff-Parkinson-White Syndrome. Among its related pathways are Gene expression (Transcription) and Transmission across Chemical Synapses.

AMP-activated protein kinase is a key regulator of obesity-associated factors. PRKAA1, stabilized by FTO in an m6A-YTHDF2-dependent manner, promotes cell proliferation and glycolysis of gastric cancer by regulating the redox balance.

Nov 7, 2018 · Selective deletion of endothelial Prkaa1, coding for protein kinase AMP-activated catalytic subunit alpha1, reduces glycolysis, compromises endothelial cell proliferation, and accelerates the...

Feb 11, 2025 · Enables AMP-activated protein kinase activity; chromatin binding activity; and histone H2BS36 kinase activity. Involved in several processes, including negative regulation of TORC1 signaling; regulation of organelle organization; and regulation of …

Dec 10, 2024 · Clinical resource with information about PRKAA1, A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

PRKAA1 (protein kinase AMP-activated catalytic subunit α 1) is a catalytic subunit of AMP-activated protein kinase (AMPK), which plays a key role in regulating cellular energy metabolism through phosphorylation, and genetic variations in the PRKAA1 ...

Jul 1, 2018 · Protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), also known as AMPK α1, is an energy sensor that plays a key role in the regulation of cellular energy metabolism. AMPK α1 is the catalytic subunit of the heterotrimeric AMPK protein with a length of 548 amino acids.

HGNC Approved Gene Symbol: PRKAA1. Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38) : 5:40,759,389-40,798,374 (from NCBI) The mammalian 5-prime-AMP-activated protein kinase (AMPK) appears to play a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.

Jan 16, 2024 · AMPK is a heterotrimeric protein consisting of α, β, and γ subunits. The independent functions of the 2 isoforms of the catalytic α subunit, PRKAA1 and PRKAA2, are uncharacterized in specialized neurons, such as photoreceptors.

PRKAA1 is a prognostic marker in Kidney renal clear cell carcinoma, Ovary serous cystadenocarcinoma