Dec 25, 2024 · PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) is a Protein Coding gene. Diseases associated with PMAIP1 include Leukemia and Mantle Cell Lymphoma. Among its related pathways are Intrinsic Pathway for Apoptosis and Gene expression (Transcription).

PMAIP1 is participate in hippocampal neuron damage by regulating mitochondrial function. Keywords: Alzheimer's disease, Apoptosis, Biomarkers, Mitochondrial Metabolism. This study explored novel biomarkers that can affect the diagnosis and treatment in Alzheimer's Disease (AD) related to mitochondrial metabolism.

Jan 29, 2025 · Mechanistically, PMAIP1 regulated FOSL1 by modulating the Wnt signaling pathway, thereby promoting FTC progression. Targeting PMAIP1 may present a promising therapeutic strategy for FTC.

The model was used to classify clinical subtypes of breast cancer, and PMAIP1 was identified as a potential critical gene related to glucose metabolism in breast cancer. Single-cell analysis and Bayes deconvolution jointly confirmed the protective role of the PMAIP1+ luminal cell cluster.

The mechanism of mitochondrial metabolic gene PMAIP1 involved in Alzheimer's disease process based on bioinformatics analysis and experimental validation. Noxa inhibits oncogenesis through ZNF519 in gastric cancer and is suppressed by hsa-miR-200b-3p.

A comprehensive evaluation of all the network analyses, PMAIP1 was defined as osteoporosis’s core gene. This conclusion was further confirmed in clinical cohort data. A series of experiments demonstrated that the PMAIP1 gene can promote the osteogenesis, migration and proliferation of …

PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1) was identified as the critical hub gene of breast cancer prognosis associated with glucose metabolism, and its regulation to tumor phenotypes were validated in a breast cancer cell line. Bulk sequencing (bulk-seq) further revealed variations in glucose metabolism at the cell line level.

Apr 30, 2024 · PMAIP1 was a potential candidate gene that may affect mitochondrial function in Hippocampal neuronal cells, and its mechanism deserves further study. This study identified biomarkers related to mitochondrial metabolism in AD and provided a theoretical basis for the diagnosis of AD.

Feb 8, 2025 · Pmaip1 protein deficiency alone also increased B-lineage cells but did not accelerate lymphomagenesis. Bmi1 controls memory CD4(+) Th1/Th2 cell survival and functions through the direct repression of the Noxa gene.

HGNC Approved Gene Symbol: PMAIP1. Cytogenetic location: 18q21.32 Genomic coordinates (GRCh38) : 18:59,899,996-59,904,305 (from NCBI) To identify genes involved in leukemogenesis of adult T-cell leukemia (ATL), Hijikata et al. (1990) constructed a cDNA library from an ATL tumor cell line named IKD.