PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle regulation and is expressed predominantly during the G2/S and M phase of the cell cycle. PLK1-mediated phosphorylation of specific substrates controls cell entry into mitosis, centrosome maturation, spindl …

2024年12月25日 · PLK1 (Polo Like Kinase 1) is a Protein Coding gene. Diseases associated with PLK1 include Gonococcal Keratitis and Epilepsy. Among its related pathways are Loss of proteins required for interphase microtubule organization from the centrosome and EML4 and NUDC in mitotic spindle formation.

In this article, we examined PLK1's structural characteristics, its regulatory roles in cell mitosis, PLK1 expression, and its association with survival prognoses of cancer patients in a wide variety of cancer types, PLK1 interaction networks, and PLK1 inhibitors under investigation.

2024年12月30日 · Polo-like kinase 1 (PLK1) protects against genome instability by ensuring timely and accurate mitotic cell division, and its activity is tightly regulated throughout the cell cycle.

In this review, we first discuss structure and function of PLK1, role of PLK1 in cancers, PLK1 specific inhibitors, and advantages of using combination therapy versus monotherapy followed by a critical account on PLK1-based combination therapies in cancer treatments, especially highlighting recent advancements and challenges.

2006年4月1日 · Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in cancer,...

PLK1, a serine/threonine protein kinase belonging to CDC5/Polo subfamily, plays a promotive role during mitosis. 21 As mentioned in the literature reviews, PLK1 regulates centrosome maturation and assemblies the bipolar spindle. 22 PLK1 is also known as an important component for removing the cohesins from chromosome arms.

Polo-like kinase 1 (Plk1), a well-characterized member of serine/threonine kinases Plk family, has been shown to play pivotal roles in mitosis and cytokinesis in eukaryotic cells. Recent studies suggest that Plk1 not only controls the process of ...

2025年3月7日 · PLK1 is overexpressed in prostate cancer and is one of the top five signalling pathways upregulated in castration-resistant prostate cancer, highlighting the importance of developing potent PLK1 inhibitors as a therapeutic strategy for prostate cancer. In this study, we successfully identified five novel and potent PLK1 inhibitors (Hits 1–5 ...

2025年3月3日 · The role of plk1 in the regulation of mitotic entry has been studied earlier, but the specific stage at which plk1 inhibition delays cells during mitotic entry, and generally whether plk1 is essential for mitotic entry, remained somewhat contentious (Gheghiani et al, 2017; Lénárt et al, 2007). To find answers to these questions, we inhibited ...