Dec 25, 2024 · PLD1 (Phospholipase D1) is a Protein Coding gene. Diseases associated with PLD1 include Cardiac Valvular Dysplasia 1 and Heart Disease. Among its related pathways …

该基因编码磷脂酰胆碱特异性磷脂酶，该酶催化磷脂酰胆碱的水解以产生磷脂酸和胆碱。 该酶可能在信号转导和亚细胞运输中发挥作用。 可变剪接导致具有催化和调节特性的多个转录变体。 …

PLD信号通路是细胞内的一种次级信号传递系统，通过PLD代谢产物——PA的作用，参与调控多种生物学过程，包括细胞分化、增殖、运动、内质网应激反应以及膜结构、细胞架构的改变等。 …

As PLD1 is a novel target of vorinostat resistance, combination therapy with PLD1 inhibitors and vorinostat may represent a potential therapeutic strategy against GBM tumorigenesis. …

Phospholipase D1 (PLD1) is an enzyme that in humans is encoded by the PLD1 gene, [5][6] though analogues are found in plants, fungi, prokaryotes, and even viruses. [7] The possibility …

Jan 4, 2025 · Title: PLD1 knockdown reduces metastasis and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by modulating NF-κB and Wnt/β-catenin pathways. RalA …

PLD1 is threonine-phosphorylated in human-airway epithelial cells by a PKCdelta and src dependent mechanism; PLD1 may play a crucial role in collagen type I production through …

Oct 18, 2019 · 10 月 16 日， Cell research 在线发表了中国科学院分子植物科学卓越创新中心张鹏研究组题为 Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of …

May 16, 2017 · Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting …

Jul 1, 2024 · PLD1 inhibition specifically targets GSCs but not neuroprogenitor cells. PLD1 depletion sensitizes GSCs to the effect of TMZ on GSC‐derived intracranial tumors 17.