2024年12月25日 · PLD1 (Phospholipase D1) is a Protein Coding gene. Diseases associated with PLD1 include Cardiac Valvular Dysplasia 1 and Heart Disease. Among its related pathways …

2024年7月1日 · Aberrant dysregulation of phospholipase D (PLD) has been implicated in several malignancies, and oncogenic activation of this pathway facilitates tumor proliferation, …

Phospholipase D1 (PLD1) is generally accepted as playing an important role in the regulation of multiple cell functions, such as cell growth, survival, differentiation, membrane trafficking, and …

2017年2月17日 · PLD1 allosterically modulates the activity of mechanistic target of rapamycin (mTOR), which leads to the phosphorylation of CAD and enhances its catalytic activity.

PLD1 is threonine-phosphorylated in human-airway epithelial cells by a PKCdelta and src dependent mechanism; PLD1 may play a crucial role in collagen type I production through …

2017年5月16日 · Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists …

2020年3月16日 · The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays …

2025年1月4日 · Title: PLD1 knockdown reduces metastasis and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by modulating NF-κB and Wnt/β-catenin pathways. RalA …

PLD1 and PLD2 have emerged as promising pharmaceutical targets with increased PLD1/2 activity and expression linked to tumor growth, neurodegeneration and various blood disorders.

Genetic and pharmacological targeting of PLD1 conferred protection against LPS-induced sepsis, cardiotoxin-induced muscle injury, and skin injury by promoting the shift toward M2; PLD2 …