2024年12月25日 · PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases associated with PLAU include Quebec Platelet Disorder and Alzheimer Disease, Familial, 1. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Innate Immune System.

Urokinase is encoded in humans by the PLAU gene, which stands for "plasminogen activator, urokinase". [7] The same symbol represents the gene in other animal species.

Plau am See (German: [plaʊ̯ am ˈzeː] ⓘ) is a town in the Ludwigslust-Parchim district, in Mecklenburg-Western Pomerania, in north-eastern Germany. It is situated 28 kilometres (17 mi) east of Parchim, and 29 kilometres (18 mi) west of Waren.

2021年2月11日 · We explored the function of PLAU in ESCC and the influence of PLAU secreted by tumor cells on the heterogeneity of CAFs. We found that PLAU is highly expressed in ESCC, which is related to...

PLAU is a promising new candidate gene for late-onset Alzheimer's disease, with allele C (P141) being a recessive risk allele or allele T (L141) conferring protection. u-PA down-regulation by RNAi technology decreases the invasive capability of hepatocellular carcinoma cells

2025年1月4日 · Title: PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway. Gene Association Study of the Urokinase Plasminogen Activator and Its Receptor Gene in Alzheimer's Disease.

2024年1月17日 · Plasminogen activator urokinase (PLAU), also named urokinase-type plasminogen activator (uPA), is a serine protease that catalyzes the transformation of plasminogen to plasmin [15]. It regulates tissue remodeling and cell migration. Accumulating evidence has linked PLAU to oncogenesis [16, 17, 18].

2021年5月20日 · Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. However, the biological functions and potential mechanisms of PLAU in head and neck squamous cell …

Previous studies have revealed the role of dysregulated urokinase plasminogen activator (encoded by PLAU) expression and activity in several pathways associated with cancer progression.

2012年11月20日 · We show that a predicted top-ranked new key gene PLAU (the plasminogen activator urokinase) is important for the suppressor function of both human and murine Tregs. Further analysis unveils that PLAU is particularly important for memory Tregs and that PLAU mediates Treg suppressor function via STAT5 and ERK signaling pathways.