2024年12月25日 · PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases associated with PLAU include Quebec Platelet Disorder and Alzheimer Disease, Familial, 1. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Innate Immune System.

Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein was discovered, but not named, by McFarlane and Pilling in 1947. [5] .

2025年1月4日 · Title: PLAU contributes to the development of cholangiocarcinoma via activating NF-κB signaling pathway. Involvement of matrix metalloproteinase 1 and urokinase-type plasminogen activator in the PKCalpha-p38 MAPK pathway-mediated progression of …

PLAU is a promising new candidate gene for late-onset Alzheimer's disease, with allele C (P141) being a recessive risk allele or allele T (L141) conferring protection. u-PA down-regulation by RNAi technology decreases the invasive capability of hepatocellular carcinoma cells

2025年1月4日 · Clinical resource with information about PLAU, Alzheimer disease type 1, Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease., Quebec platelet disorder, and available tests.

2021年5月20日 · Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. However, the biological functions and potential mechanisms of PLAU in head and neck squamous cell …

2023年8月28日 · PLAU is a protease that converts plasminogen to plasmin. It appears to affect murine ageing: its overexpression in the brain diminishes food consumption and extends longevity probably through a mechanism similar to caloric restriction [13].