Dec 25, 2024 · PDLIM5 (PDZ And LIM Domain 5) is a Protein Coding gene. Diseases associated with PDLIM5 include Bipolar Disorder and Nail-Patella Syndrome. Among its related pathways are Protein-protein interactions at synapses and Transmission across Chemical Synapses.

In this review, we briefly summarize the state of knowledge on the PDLIM5 gene, structural properties, and molecular functional mechanisms of the PDLIM5 protein, and its role in cells, tissues, and organ systems, and describe the possible underlying molecular signaling pathways.

Aug 7, 2020 · In this review, we briefly summarize the state of knowledge on the PDLIM5 gene, structural properties, and molecular functional mechanisms of the PDLIM5 protein, and its role in cells, tissues, and organ systems, and describe the …

Feb 9, 2025 · Mechanical Sensing Element PDLIM5 Promotes Osteogenesis of Human Fibroblasts by Affecting the Activity of Microfilaments. Mutations in PDLIM5 are rare in dilated cardiomyopathy but are emerging as potential disease modifiers.

PDZ and LIM domain 5 (PDLIM5) is a cytoskeleton-associated protein and has been shown to bind to a variety of proteins through its specific domain, thereby acting to regulate cell migration and tumor progression. Here, we found that PDLIM5 was abnormally upregulated in prostate cancer (PCa) tissues as compared with that in normal prostate tissue.

Dec 27, 2019 · We observed a correlation between LVEF and PDLIM5 expression, with a decrease in PDLIM5 expression with decreasing LVEF in patients without a PDLIM5 LoF variant. In contrast, our patient with a frameshift mutation had an increased expression of PDLIM5 despite of a low LVEF of 10%.

Oct 2, 2020 · Collectively, our findings indicate that PDLIM5 is a novel regulator of basal SMAD3 stability, with implications for controlling TGFβ signaling and NSCLC progression. Keywords: E3 ubiquitin ligase; ENH; STUB1; cell invasion; cell motility; invasion; lung cancer; proteasome degradation; protein degradation; signal transduction; transforming ...

PDZ and LIM domain 5 (PDLIM5) is regarded as a cytoskeleton-related protein that is intimately connected to the dynamic alterations of microfilaments and can mediate signal transmissions between the cell nucleus and the cytoskeleton.

Title: PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells. Novel polymorphisms in PDLIM3 and PDLIM5 gene encoding Z-line proteins increase risk of idiopathic dilated cardiomyopathy.

May 5, 2018 · We found that knockdown of PDLIM5 expression in the B-CPAP cell line could inhibit the migration, invasion and proliferation of PTC cells. In addition, PDLIM5 knockdown reduced Ras and Phospho-ERK1/2 expression. Thus, we suggested that PDLIM5 promotes PTC via activation of the Ras-ERK pathway.